Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Biguanide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biguanide SCHEMBL28232006 | 0.96 | — | — | |
| Biguanide SCHEMBL8039 | 0.95 | — | — | |
| Biguanide SCHEMBL18255803 | 0.95 | MAPK1 (0.31) | — | |
| Biguanide SCHEMBL4217126 | 0.91 | — | — | |
| Biguanide SCHEMBL1428352 | 0.91 | — | — | |
| Biguanide SCHEMBL30340358 | 0.91 | — | — | |
| Biguanide SCHEMBL10881314 | 0.91 | — | — | |
| Biguanide SCHEMBL675101 | 0.91 | — | — | |
| Biguanide SCHEMBL4221594 | 0.91 | — | — | |
| Biguanide SCHEMBL31013828 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070086977-A1 | Method of treating dermatological conditions | STOCKEL RICHARD F | 2007-04-19 | — | — | US | claimed |
| US-20050136024-A1 | Dermatological compositions | BRIDGEWATER INTELLECTUAL PROPERTIES LLC | 2005-06-23 | — | — | US | claimed |
| CN-115477783-B | Method for preparing chitin-based super absorbent material, gel and application thereof | 西湖大学 | 2023-10-24 | — | — | CN | disclosed |
| CN-111393638-A | Dissolution-resistant guanidine antibacterial agent and preparation method thereof | 安阳崇高纳米材料科技有限公司 | 2020-07-10 | — | — | CN | disclosed |
| CN-106574932-A | Biochemical markers for use in determining risk of diabetes | 沃拉克有限公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-104105485-B | Acc inhibitors and uses thereof | 吉利德阿波罗公司 | 2017-04-12 | — | — | CN | disclosed |
| US-20070086977-A1 | Method of treating dermatological conditions | STOCKEL RICHARD F | 2007-04-19 | — | — | US | disclosed |