Biguanide

Biguanide

SCHEMBL1428352

Cl.N=C(N)NC(=N)N

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Biguanide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biguanide SCHEMBL27289754 1.00
Biguanide SCHEMBL10881314 1.00
Biguanide SCHEMBL29238595 0.96
Biguanide SCHEMBL28232006 0.96
Biguanide SCHEMBL28969429 0.96
Biguanide SCHEMBL8039 0.95
Biguanide SCHEMBL18255803 0.95 MAPK1 (0.31)
Biguanide SCHEMBL28114558 0.92
Biguanide SCHEMBL4217126 0.91
Biguanide SCHEMBL31013828 0.91

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 842 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108946-A1 LOW-TEMPERATURE CASE HARDENING OF ADDITIVE MANUFACTURED ARTICLES AND MATERIALS AND TARGETED APPLICATION OF SURFACE MODIFICATION SWAGELOK CO (US) 2026-04-23 US claimed
US-20260002244-A1 ACTIVATION OF SELF-PASSIVATING METALS USING REAGENT COATINGS FOR LOW TEMPERATURE NITROCARBURIZATION IN THE PRESENCE OF OXYGEN-CONTAINING GAS SWAGELOK CO (US) 2026-01-01 US claimed
US-12435406-B2 Activation of self-passivating metals using reagent coatings for low temperature nitrocarburization in the presence of oxygen-containing gas SWAGELOK COMPANY (US) 2025-10-07 US claimed
US-20250297351-A1 LASER-ASSISTED REAGENT ACTIVATION AND PROPERTY MODIFICATION OF SELF-PASSIVATING METALS SWAGELOK COMPANY 2025-09-25 US claimed
CN-116621782-B Antibacterial formaldehyde-removing odor-removing material and preparation method and application thereof 广东迪美生物技术有限公司 2025-06-13 CN claimed
CN-119430582-B Method and system for concentrating and reducing evaporation pond in short process 杭州上拓环境科技股份有限公司 2025-05-13 CN claimed
US-20250066289-A1 BIGUANIDE DERIVATIVE OF IBUPROFEN AND PROCESS OF PREPARATION THEREOF BVDU'S POONA COLLEGE OF PHARMACY (IN) 2025-02-27 US claimed
CN-119463434-A High-performance antibacterial and detoxifying high polymer material and preparation method thereof 中氪新能源科技(上海)有限公司 2025-02-18 CN claimed
CN-114929924-B Chemical activation of self-passivating metals 斯瓦戈洛克公司 2025-02-14 CN claimed
CN-119430582-A Method and system for concentrating and reducing evaporation pond in short process 杭州上拓环境科技股份有限公司 2025-02-14 CN claimed
WO-2006067439-A1 A METHOD OF DISINFECTING TEXTILE ARTICLES DURING LAUNDERING AND A LAUNDRY PREPARATION QUILL INTERNATIONAL INDUSTRIES PLC (GB) 2006-06-29 WO claimed
US-20060127337-A1 Process for relaxing keratin fibres L'OREAL (FR) 2006-06-15 US claimed
CN-1778840-A Capsule composition and preparation method thereof BAONENG SCIENCE AND TECHNOLOGY (CN) 2006-05-31 CN claimed
EP-1638895-A2 UNCOUPLING AGENTS Rhodia UK Limited (GB) 2006-03-29 EP claimed
WO-2004113236-A2 UNCOUPLING AGENTS RHODIA UK LTD (GB) 2004-12-29 WO claimed
US-20030057401-A1 Inhibitor compositions CHAMPION TECHNOLOGIES INC. 2003-03-27 US claimed
WO-2001036713-A1 INHIBITOR COMPOSITIONS CHAMPION TECHNOLOGIES INC. (US) 2001-05-25 WO claimed
WO-2000014193-A1 COMPOSITION FOR THE REMOVAL OF BIOLOGICAL AND ORGANIC SUBSTANCES MACGREGOR, KEITH, MARTIN (GB) 2000-03-16 WO claimed
CN-1038248-C Diguanide derivatives, process of preparation thereof and disinfetants containing them OTSUKA CHEMCIAL CO LTD (JP) 1998-05-06 CN claimed
CN-1065453-A Biguanide derivative, its manufacture method and the Herb of Common violet that contains this derivative OTSUKA CHEMICAL CO LTD (JP) 1992-10-21 CN claimed