SCHEMBL549108

SCHEMBL549108

Nc1cc(N)cc(C(=O)Nc2cccc(C(F)(F)F)c2)c1

nearest known ligand 0.73

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.73
PTGS1 P23219 5/20 0.72
KCNK3 O14649 2/20 0.63
P2RX1 P51575 1/20 0.62
LMNA P02545 1/20 0.62
MEN1 O00255 2/20 0.61
KMT2A Q03164 2/20 0.61
TSHR P16473 1/20 0.61
RXFP1 Q9HBX9 2/20 0.61
HTT P42858 1/20 0.60
RAB9A P51151 1/20 0.60
ALDH1A1 P00352 1/20 0.60
MAOA P21397 1/20 0.60
MAOB P27338 1/20 0.60
KCNK9 Q9NPC2 1/20 0.59
BTK Q06187 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4463935 0.90 PTGS1 (0.89) MAPTPTGS1KCNK3P2RX1LMNA
SCHEMBL11307930 0.88 PTGS1 (0.76) MAPTPTGS1KCNK3P2RX1LMNA
SCHEMBL4464994 0.87 MAPT (0.69) MAPTPTGS1RXFP1HTT
SCHEMBL24141032 0.86 MAPT (0.84) MAPTPTGS1KCNK3P2RX1LMNA
SCHEMBL28329635 0.84 P2RX1 (0.64) MAPTPTGS1P2RX1
SCHEMBL23447711 0.84 MAPT (0.82) MAPTPTGS1KCNK3P2RX1LMNA
SCHEMBL4286068 0.84 MAPT (0.94) MAPTPTGS1KCNK3P2RX1LMNA
SCHEMBL2861430 0.84 PTGS1 (1.00) MAPTPTGS1KCNK3P2RX1LMNA
SCHEMBL13066011 0.84 HDAC3 (0.55) MAPTPTGS1KCNK3MEN1KMT2A
SCHEMBL6836448 0.84 MAPT (0.80) MAPTPTGS1KCNK3P2RX1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 250 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5756649-A HAVING THE ABILITY TO CHANGE THE PRETILT ANGLE WITH RADIATION JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1998-05-26 US claimed
EP-4634327-A1 COMPOSITION FOR FORMING A LIQUID CRYSTAL ALIGNMENT FILM Rolic Technologies AG (CH) 2025-10-22 EP disclosed
US-12386258-B2 Chain extenders and formulations thereof for improving elongation in photosensitive polyimide HUTCHINSON TECHNOLOGY INCORPORATED (US) 2025-08-12 US disclosed
US-12269948-B2 Polyimide precursor solution and method for producing porous polyimide film FUJIFILM BUSINESS INNOVATION CORP. (JP) 2025-04-08 US disclosed
WO-2025070654-A1 MATERIAL FOR PRINTED WIRING BOARDS AND METHOD FOR MANUFACTURING PRINTED WIRING BOARD 東洋アルミニウム株式会社 2025-04-03 WO disclosed
WO-2025070655-A1 MATERIAL FOR PRINTED WIRING BOARDS AND METHOD FOR MANUFACTURING PRINTED WIRING BOARD 東洋アルミニウム株式会社 2025-04-03 WO disclosed
US-12259671-B2 Resin belt, fixing belt, fixing device, and image forming apparatus FUJIFILM BUSINESS INNOVATION CORP. (JP) 2025-03-25 US disclosed
US-12253815-B2 Endless belt, fixing belt, fixing device, and image forming apparatus FUJIFILM BUSINESS INNOVATION CORP. (JP) 2025-03-18 US disclosed
US-12247103-B2 Polyimide precursor solution, porous polyimide film, separator for secondary battery, and secondary battery FUJIFILM BUSINESS INNOVATION CORP. (JP) 2025-03-11 US disclosed
CN-113054322-B Porous polyimide film, separator for secondary battery, and secondary battery 富士胶片商业创新有限公司 2025-03-04 CN disclosed
US-20020055610-A1 Novel polyimide compositions and novel acid dianhydrides to be used therein KANEKA CORPORATION (JP) 2002-05-09 US disclosed
US-6350845-B1 POLYAMIDEIMIDE COPOLYMERS FOR NONABSORBENT HEAT RESISTANT COMPOSITIONS KANEKA CORPORATION (JP) 2002-02-26 US disclosed
US-20020019558-A1 Diamine and acid anhydride KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2002-02-14 US disclosed
US-20010056174-A1 Epoxy-modified polyimide, photosensitive composition, coverlay film, solder resist, and printed wiring board using the epoxy-modified polyimide KANEKA CORPORATION (JP) 2001-12-27 US disclosed
US-6307002-B1 POLYIMIDES FROM TETRAACIDS AND DIAMINES KANEKA CORPORATION (JP) 2001-10-23 US disclosed
US-6303742-B1 CHARACTERIZED BY A CINNAMOYL GROUP OR A DERIVED CINNAMOYL GROUP INCORPORATED THEREIN AND BY PHOTO-REACTIVITY AND HEAT-REACTIVITY WHICH ARE INHERENT IN THE CINNAMOYL GROUP. KANEKAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2001-10-16 US disclosed
US-5773559-A POLYAMIC ACID, POLYIMIDE BLOCK POLYMERS JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1998-06-30 US disclosed
US-5756649-A HAVING THE ABILITY TO CHANGE THE PRETILT ANGLE WITH RADIATION JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1998-05-26 US disclosed
US-5612450-A POLYAMIC ACID-POLYIMIDE COPOLYMER FILMS JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1997-03-18 US disclosed
EP-0683418-A2 Liquid crystal aligning agent and liquid crystal display device JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1995-11-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020019558-A1 Diamine and acid anhydride CA1, ASIC1, CA4 MAPT 573/4885PTGS1 2385/4885KCNK3 4401/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.