Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.48 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.48 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28572813 | 0.86 | PRMT5 (0.49) | CASP3SENP8SENP7SENP6PRMT5 | |
| SCHEMBL30546488 | 0.86 | CASP3 (0.58) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL2246941 | 0.82 | CASP3 (0.55) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL22803978 | 0.78 | MTOR (0.53) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL30344399 | 0.78 | CASP3 (0.77) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL5443742 | 0.78 | CASP3 (0.77) | CASP3SENP8SENP7SENP6NPC1 | |
| Hydrochloric Acid SCHEMBL28847796 | 0.77 | PRMT5 (0.67) | CASP3SENP8SENP7SENP6PRMT5 | |
| SCHEMBL15060321 | 0.74 | NAMPT (0.59) | NPC1RAB9ANAMPTPDE10AMAPT | |
| SCHEMBL3704691 | 0.74 | CASP3 (1.00) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL4408484 | 0.74 | PRMT5 (0.57) | CASP3SENP8SENP7SENP6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183252-B2 | Indole peptidomimetics as thrombin receptor antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-02-27 | — | — | US | disclosed |
| US-6858577-B1 | Indole peptidomimetics as thrombin receptor antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-02-22 | — | — | US | disclosed |
| US-20030224999-A1 | Novel indole peptidomimetics as thrombin receptor antagonists | ZHANG HAN-CHENG (US) | 2003-12-04 | — | — | US | disclosed |
| US-20020103138-A1 | Method for reducing or preventing the establishment, growth or metastasis of cancer by administering indole peptidomimetics PAR-1 antagonist and optionally PAR-2 antagonists | ORTHO-MCNEIL PHARMACEUTICAL CORPORATION | 2002-08-01 | — | — | US | disclosed |
| WO-2001000657-A2 | NOVEL INDOLE PEPTIDOMIMETICS AS THROMBIN RECEPTOR ANTAGONISTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103138-A1 | Method for reducing or preventing the establishment, growth or metastasis of cancer by administering indole peptidomimetics PAR-1 antagonist and optionally PAR-2 antagonists | F2RL1, F2R, IDO2 | CASP3 938/4885SENP8 2004/4885SENP7 1544/4885 |
| US-20030224999-A1 | Novel indole peptidomimetics as thrombin receptor antagonists | PTAFR, F2R, F2RL1 | CASP3 1321/4885SENP8 2282/4885SENP7 1917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.