Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ethylestrenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR known ✓ | P10275 | 3/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.88 |
| ▸ | ESR1 | P03372 | 5/20 | 0.88 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.88 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.88 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.88 |
| ▸ | ACHE | P22303 | 1/20 | 0.88 |
| ▸ | LMNA | P02545 | 6/20 | 0.71 |
| ▸ | PGR | P06401 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.66 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylestrenol SCHEMBL147908 | 0.94 | SLC6A4 (1.00) | SLC6A4ESR1CYP2C19CHRM2SLC6A2 | |
| Ethylestrenol SCHEMBL11217999 | 0.94 | SLC6A4 (1.00) | SLC6A4ESR1CYP2C19CHRM2SLC6A2 | |
| Ethylestrenol SCHEMBL28817294 | 0.88 | SLC6A4 (0.89) | SLC6A4ESR1CYP2C19CHRM2SLC6A2 | |
| Allylestrenol SCHEMBL19645390 | 0.83 | ESR1 (1.00) | SLC6A4ESR1CYP2C19CHRM2SLC6A2 | |
| Allylestrenol SCHEMBL29648200 | 0.83 | ESR1 (1.00) | SLC6A4ESR1CYP2C19CHRM2SLC6A2 | |
| Allylestrenol SCHEMBL329623 | 0.83 | ESR1 (1.00) | SLC6A4ESR1CYP2C19CHRM2SLC6A2 | |
| Allylestrenol SCHEMBL10406336 | 0.83 | ESR1 (1.00) | SLC6A4ESR1CYP2C19CHRM2SLC6A2 | |
| SCHEMBL11856861 | 0.80 | SLC6A4 (0.75) | SLC6A4ESR1CYP2C19CHRM2SLC6A2 | |
| SCHEMBL21807745 | 0.80 | CYP2C19 (0.74) | SLC6A4ESR1CYP2C19CHRM2SLC6A2 | |
| Lynestrenol SCHEMBL9699960 | 0.79 | PGR (1.00) | SLC6A4ESR1CYP2C19CHRM2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062198-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECHNOLOGY, INC. (US) | 2007-05-31 | — | — | WO | disclosed |