Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5490055 | 0.84 | KMO (0.45) | KMOKDM4ETP53TSHRMEN1 | |
| SCHEMBL4159940 | 0.81 | CASP7 (0.48) | KMOKDM4ETP53TSHRMEN1 | |
| SCHEMBL3205812 | 0.81 | KDM4E (0.52) | KMOKDM4ETP53TSHRALDH1A1 | |
| SCHEMBL3106043 | 0.80 | KMO (0.46) | KMOKDM4ETP53TSHRMEN1 | |
| SCHEMBL15003880 | 0.78 | NPC1 (0.46) | KDM4ETSHRALDH1A1POLBNPC1 | |
| SCHEMBL14742285 | 0.76 | KMO (1.00) | KMOALDH1A1MAPTHTT | |
| SCHEMBL14758367 | 0.76 | KMO (1.00) | KMOTSHRALDH1A1MAPTHTT | |
| SCHEMBL3114681 | 0.75 | AKT1 (0.45) | KMOKMT2AALDH1A1POLBHTT | |
| Hydrochloric Acid SCHEMBL18628102 | 0.75 | KMO (0.98) | KMOTSHRALDH1A1MAPTHTT | |
| SCHEMBL4167841 | 0.74 | CYP1A2 (0.52) | KMOKDM4ETP53TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819341-A2 | IL-12 MODULATORY COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006053227-A2 | IL-12 MODULATORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2006-05-18 | — | — | WO | disclosed |