Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596359 | 0.74 | NPC1 (0.56) | KDM4ETSHRALDH1A1HTTMAPT | |
| SCHEMBL3596358 | 0.74 | NPC1 (0.56) | KDM4ETSHRALDH1A1HTTMAPT | |
| SCHEMBL27916117 | 0.71 | KDM4E (0.56) | KDM4ETSHRALDH1A1HTTMAPT | |
| SCHEMBL9381965 | 0.71 | ALDH1A1 (0.68) | KDM4ETSHRALDH1A1HTTMAPT | |
| SCHEMBL18030327 | 0.70 | NPC1 (0.51) | KDM4ETSHRALDH1A1HTTMAPT | |
| SCHEMBL16795693 | 0.70 | TP53 (0.47) | KDM4ETSHRALDH1A1HTTMAPT | |
| SCHEMBL2474693 | 0.69 | NPC1 (1.00) | KDM4ETSHRALDH1A1HTTMAPT | |
| SCHEMBL30242943 | 0.69 | NPC1 (1.00) | KDM4ETSHRALDH1A1HTTMAPT | |
| Dipyridyl SCHEMBL8655605 | 0.66 | KDM4E (0.93) | KDM4ETSHRALDH1A1HTTMAPT | |
| Dipyridyl SCHEMBL8962334 | 0.66 | KDM4E (0.93) | KDM4ETSHRALDH1A1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070255061-A1 | 5-Fluoro-, Chloro-and Cyano-Pyridin-2-Yl-Tetrazoles as Ligands of the Metabotropic Glutamate Receptor-5 | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | US | disclosed |
| CN-1906187-A | 5-fluoro-, chloro- and cyano-pyridin-2-yl-tetrazoles as ligands of the metabotropic glutamate receptor-5 | ASTRAZENECA AB (SE) | 2007-01-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070255061-A1 | 5-Fluoro-, Chloro-and Cyano-Pyridin-2-Yl-Tetrazoles as Ligands of the Metabotropic Glutamate Receptor-5 | GRM5, GRIK5, GRM1 | KDM4E 2267/4885TSHR 265/4885ALDH1A1 2648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.