Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROC | P04070 | 11/20 | 0.45 |
| ▸ | F2 | P00734 | 6/20 | 0.43 |
| ▸ | IL23R | Q5VWK5 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.37 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.37 |
| ▸ | APC | P25054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495108 | 1.00 | PROC (0.45) | PROCF2IL23RMEN1ALDH1A1 | |
| SCHEMBL14628524 | 0.91 | SIRT6 (0.43) | PROCF2IL23RMEN1ALDH1A1 | |
| SCHEMBL5496533 | 0.87 | IL23R (0.40) | PROCF2IL23RMEN1ALDH1A1 | |
| SCHEMBL5487558 | 0.86 | IL23R (0.41) | PROCF2IL23RMEN1ALDH1A1 | |
| SCHEMBL5487554 | 0.86 | IL23R (0.41) | PROCF2IL23RMEN1ALDH1A1 | |
| SCHEMBL14628517 | 0.81 | IL23R (0.38) | PROCF2IL23RMEN1ALDH1A1 | |
| SCHEMBL5504726 | 0.78 | MEN1 (0.41) | PROCF2IL23RMEN1ALDH1A1 | |
| SCHEMBL5495671 | 0.78 | MEN1 (0.41) | PROCF2IL23RMEN1ALDH1A1 | |
| SCHEMBL5489574 | 0.74 | F2 (0.53) | PROCF2 | |
| SCHEMBL14598258 | 0.72 | PROC (0.44) | PROCF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753782-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20070004644-A1 | Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia | SIRCAR JAGADISH C | 2007-01-04 | — | — | US | disclosed |
| WO-2005123770-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004644-A1 | Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia | CETP, LDLR, NPC1L1 | PROC 569/4885F2 3991/4885IL23R 2980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.