Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PROC | P04070 | 6/20 | 0.39 |
| ▸ | IL23R | Q5VWK5 | 1/20 | 0.39 |
| ▸ | APC | P25054 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495671 | 1.00 | MEN1 (0.41) | MEN1ALDH1A1HPGDKMT2APROC | |
| SCHEMBL5496533 | 0.92 | IL23R (0.40) | MEN1ALDH1A1HPGDKMT2APROC | |
| SCHEMBL14598343 | 0.88 | MEN1 (0.41) | MEN1ALDH1A1HPGDKMT2APROC | |
| SCHEMBL14628524 | 0.79 | SIRT6 (0.43) | MEN1ALDH1A1HPGDKMT2APROC | |
| SCHEMBL5492067 | 0.78 | PROC (0.45) | MEN1ALDH1A1HPGDKMT2APROC | |
| SCHEMBL5495127 | 0.76 | PROC (0.38) | HPGDPROCF2 | |
| SCHEMBL14598344 | 0.75 | PROC (0.35) | PROCF2 | |
| SCHEMBL14628529 | 0.75 | MEN1 (0.51) | MEN1ALDH1A1HPGDKMT2AAPC | |
| SCHEMBL5495697 | 0.75 | DRD3 (0.39) | MEN1ALDH1A1HPGDKMT2AFOLH1 | |
| SCHEMBL5487558 | 0.74 | IL23R (0.41) | MEN1ALDH1A1HPGDKMT2APROC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753782-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005123770-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2005-12-29 | — | — | WO | disclosed |