Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921405 | 0.80 | GAA (0.52) | ALDH1A1SMN1; SMN2LMNAKMT2APOLB | |
| SCHEMBL4647745 | 0.80 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2LMNAKMT2ANPC1 | |
| SCHEMBL29503140 | 0.78 | PRSS1 (0.61) | ALDH1A1SMN1; SMN2LMNAATMKMT2A | |
| SCHEMBL1002832 | 0.78 | PRSS1 (0.61) | ALDH1A1SMN1; SMN2LMNAATMKMT2A | |
| SCHEMBL17774908 | 0.78 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2LMNAATMKMT2A | |
| SCHEMBL31549984 | 0.78 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2LMNAKMT2ANPC1 | |
| SCHEMBL1155655 | 0.78 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2LMNAKMT2ANPC1 | |
| SCHEMBL30508518 | 0.78 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2LMNAKMT2ANPC1 | |
| SCHEMBL15688714 | 0.77 | ROCK1 (0.52) | KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL19472697 | 0.77 | KMT2A (0.55) | ALDH1A1SMN1; SMN2KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819341-A2 | IL-12 MODULATORY COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006053227-A2 | IL-12 MODULATORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2006-05-18 | — | — | WO | disclosed |