Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 6/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 13/20 | 0.46 |
| ▸ | MMP9 | P14780 | 10/20 | 0.46 |
| ▸ | MMP1 | P03956 | 9/20 | 0.46 |
| ▸ | MMP3 | P08254 | 9/20 | 0.46 |
| ▸ | MMP7 | P09237 | 9/20 | 0.46 |
| ▸ | MMP13 | P45452 | 9/20 | 0.46 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2764111 | 1.00 | ADAMTS5 (0.78) | ADAMTS5MAPK1CYP2C19MMP2MMP9 | |
| SCHEMBL2764112 | 1.00 | ADAMTS5 (0.78) | ADAMTS5MAPK1CYP2C19MMP2MMP9 | |
| SCHEMBL2764182 | 0.92 | ADAMTS5 (0.86) | ADAMTS5MAPK1CYP2C19MMP2MMP9 | |
| SCHEMBL2764179 | 0.92 | ADAMTS5 (0.86) | ADAMTS5MAPK1CYP2C19MMP2MMP9 | |
| SCHEMBL6058646 | 0.88 | ADAMTS5 (1.00) | ADAMTS5MAPK1CYP2C19MMP2 | |
| SCHEMBL2764374 | 0.88 | ADAMTS5 (1.00) | ADAMTS5MAPK1CYP2C19MMP2 | |
| SCHEMBL2764561 | 0.88 | ADAMTS5 (1.00) | ADAMTS5MAPK1CYP2C19MMP2 | |
| SCHEMBL13398332 | 0.88 | ADAMTS5 (1.00) | ADAMTS5MAPK1CYP2C19MMP2 | |
| SCHEMBL2765163 | 0.88 | ADAMTS5 (1.00) | ADAMTS5MAPK1CYP2C19MMP2 | |
| SCHEMBL2764668 | 0.88 | ADAMTS5 (1.00) | ADAMTS5MAPK1CYP2C19MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007516982-A | — | — | 2007-06-28 | — | — | JP | claimed |
| EP-1694410-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | Japan Tobacco, Inc. (JP) | 2006-08-30 | — | — | EP | claimed |
| WO-2005058884-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-06-30 | — | — | WO | claimed |