Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5492499 | 0.88 | CRHR1 (0.47) | CRHR1DRD2HTR7HTR6CNR2 | |
| SCHEMBL5489898 | 0.84 | CRHR1 (0.42) | CRHR1MC4RDRD2HTR7HTR6 | |
| SCHEMBL5493199 | 0.84 | CRHR1 (0.45) | CRHR1DRD2HTR7HTR6CNR2 | |
| SCHEMBL5492349 | 0.82 | CRHR1 (0.36) | CRHR1MC4RCNR2KDM4ENPC1 | |
| SCHEMBL5492338 | 0.76 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL5492341 | 0.76 | CRHR1 (0.37) | CRHR1MC4RCNR2KDM4ENPC1 | |
| SCHEMBL5487814 | 0.76 | CRHR1 (0.53) | CRHR1MC4RDRD2HTR7HTR6 | |
| SCHEMBL5488985 | 0.70 | CRHR1 (0.46) | CRHR1DRD2HTR7HTR6CNR2 | |
| SCHEMBL5495271 | 0.70 | CRHR1 (0.47) | CRHR1SMN1; SMN2 | |
| SCHEMBL5495624 | 0.69 | CRHR1 (0.45) | CRHR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279474-B2 | Substituted pyrrolo[2,3-d]pyrimidines as antagonists of the corticotropin releasing factor (CRF) | GLAXO GROUP LIMITED (GB) | 2007-10-09 | — | — | US | disclosed |