Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | MC4R | P32245 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495624 | 0.88 | CRHR1 (0.45) | CRHR1CNR2CNR1 | |
| SCHEMBL5489901 | 0.84 | CRHR1 (0.41) | CRHR1CNR2CNR1MC4R | |
| SCHEMBL5492346 | 0.82 | CRHR1 (0.38) | CRHR1CNR2MC4RKDM4ENPC1 | |
| SCHEMBL5492341 | 0.82 | CRHR1 (0.37) | CRHR1CNR2CNR1MC4RKDM4E | |
| SCHEMBL5492338 | 0.76 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL5492494 | 0.71 | CRHR1 (0.46) | CRHR1CNR2CNR1 | |
| SCHEMBL5492499 | 0.69 | CRHR1 (0.47) | CRHR1CNR2CNR1 | |
| SCHEMBL5495262 | 0.69 | CRHR1 (0.49) | CRHR1CNR2CNR1 | |
| SCHEMBL5495271 | 0.68 | CRHR1 (0.47) | CRHR1SMN1; SMN2 | |
| SCHEMBL5489896 | 0.67 | CRHR1 (0.40) | CRHR1MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279474-B2 | Substituted pyrrolo[2,3-d]pyrimidines as antagonists of the corticotropin releasing factor (CRF) | GLAXO GROUP LIMITED (GB) | 2007-10-09 | — | — | US | disclosed |