Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 5/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 8/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5812761 | 0.77 | PTGES (0.65) | SERPINE1PLA2G2APTGESPPARGEDNRB | |
| SCHEMBL8857037 | 0.76 | FOLH1 (0.54) | SERPINE1PLA2G2AFOLH1TP53 | |
| SCHEMBL3868032 | 0.75 | SERPINE1 (0.62) | SERPINE1PLA2G2APTGESPPARG | |
| SCHEMBL10383765 | 0.75 | FOLH1 (0.71) | PLA2G2AFOLH1TP53 | |
| SCHEMBL3845107 | 0.74 | SERPINE1 (0.58) | SERPINE1PLA2G2APTGESPPARG | |
| SCHEMBL4682706 | 0.74 | PTGER4 (0.48) | SERPINE1PTGESTP53 | |
| SCHEMBL4942946 | 0.74 | NOD2 (0.56) | SERPINE1PPARG | |
| SCHEMBL6302458 | 0.73 | SERPINE1 (0.51) | SERPINE1PTGESPPARGEDNRBEDNRA | |
| SCHEMBL6093344 | 0.72 | PPARG (0.65) | SERPINE1PLA2G2APPARGEDNRBEDNRA | |
| SCHEMBL6091159 | 0.72 | PPARG (0.65) | SERPINE1PTGESPPARGEDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397130-B1 | SUBSTITUTED INDOLE ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | WYETH CORP (US) | 2007-07-25 | — | — | EP | disclosed |
| EP-1397130-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | Wyeth (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2003000253-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | WYETH (US) | 2003-01-03 | — | — | WO | disclosed |