Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.67 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | HTR1A | P08908 | 4/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | HTR7 | P34969 | 3/20 | 0.54 |
| ▸ | HTR6 | P50406 | 3/20 | 0.54 |
| ▸ | HTR1D | P28221 | 6/20 | 0.53 |
| ▸ | HTR1B | P28222 | 5/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5396886 | 0.90 | ADRA1D (0.82) | ADRA1DADRA1BDRD2HTR1ASLC6A4 | |
| SCHEMBL5394770 | 0.88 | ADRA1D (0.64) | ADRA1DADRA1BDRD2HTR1ASLC6A4 | |
| SCHEMBL5401439 | 0.87 | ADRA1D (0.63) | ADRA1DADRA1BDRD2HTR1ASLC6A4 | |
| SCHEMBL5388158 | 0.85 | ADRA1D (0.65) | ADRA1DADRA1BDRD2HTR1ASLC6A4 | |
| SCHEMBL5405240 | 0.83 | ADRA1D (0.61) | ADRA1DADRA1BDRD2HTR1ASLC6A4 | |
| SCHEMBL5385305 | 0.81 | DRD2 (0.65) | ADRA1DDRD2HTR1ASLC6A4HTR2A | |
| SCHEMBL5500881 | 0.81 | ADRA1D (0.49) | ADRA1DADRA1BDRD2HTR1ASLC6A4 | |
| SCHEMBL5389529 | 0.80 | HTR1D (0.66) | ADRA1DDRD2HTR1ASLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL7256500 | 0.80 | ADRA1D (0.98) | ADRA1DADRA1BDRD2HTR1ASLC6A4 | |
| SCHEMBL5388941 | 0.79 | DRD2 (0.53) | ADRA1DADRA1BDRD2HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468996-B1 | Indole derivatives for the treatment of CNS disorders | LUNDBECK & CO AS H (DK) | 2007-09-26 | — | — | EP | claimed |