SCHEMBL5493084

SCHEMBL5493084

C=CCN1C=CC(c2c3nc(c(C4=CCN(CC=C)C=C4)c4ccc([nH]4)c(C4=CCN(CC=C)C=C4)c4nc(c(C5=CCN(CC=C)C=C5)c5ccc2[nH]5)C=C4)C=C3)=CC1

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TERT O14746 3/20 0.36
ENPP2 Q13822 1/20 0.34
TOP1 P11387 2/20 0.33
CYCS P99999 2/20 0.32
HTR3A P46098 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5181954 0.85 STAT3 (0.41)
SCHEMBL7589352 0.83 TERT (0.40) TERTENPP2TOP1CYCS
SCHEMBL30417810 0.82 TERT (0.40) TERTENPP2TOP1CYCS
Hydrochloric Acid SCHEMBL8183377 0.82 TERT (0.40) TERTENPP2TOP1CYCS
SCHEMBL3089988 0.81 TERT (0.41) TERTENPP2TOP1CYCS
SCHEMBL15006299 0.80 ENPP2 (0.34) TERTENPP2TOP1CYCS
SCHEMBL30417440 0.80 TERT (0.39) TERTENPP2TOP1CYCS
Hydrochloric Acid SCHEMBL8187817 0.80 TERT (0.40) TERTENPP2TOP1CYCS
Hydrochloric Acid SCHEMBL4134394 0.80 TERT (0.40) TERTENPP2TOP1CYCS
SCHEMBL3087029 0.78 TERT (0.37) TERTENPP2TOP1CYCS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140300857-A1 OPHTHALMIC FILTER ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQU E) (FR) 2014-10-09 US claimed
WO-2013084177-A1 OPHTHALMIC FILTER Essilor International (Compagnie Générale d'Optique) (FR) 2013-06-13 WO claimed
EP-2602654-A1 Ophthalmic filter Essilor International (Compagnie Générale D'Optique) (FR) 2013-06-12 EP claimed
US-20070248534-A1 Auger effect-based cancer therapy method BEN-GURION UNIVERSITY OF THE NEGEV (IL) 2007-10-25 US claimed
US-7008937-B2 Porphyrins and metalloporphyrins for inhibiting heme iron uptake FRONTIER SCIENTIFIC, INC. (US) 2006-03-07 US claimed
US-20050112058-A1 Auger effect-based cancer therapy method BEN-GURION UNIVERSITY OF THE NEGEV (IL) 2005-05-26 US claimed
US-20040254155-A1 Porphyrins and metalloporphyrins for inhibiting heme iron uptake FRONTIER SCIENTIFIC, INC. 2004-12-16 US claimed
US-12019316-B2 Color-balanced lenses exhibiting reduced blue light transmittance ESSILOR INTERNATIONAL (FR) 2024-06-25 US disclosed
EP-3296799-B1 OPTICAL ARTICLE WITH BLUE CUT, HIGH UV CUT AND HIGH CLARITY ESSILOR INT (FR) 2024-05-22 EP disclosed
EP-2602655-B1 Ophthalmic filter ESSILOR INT (FR) 2024-04-03 EP disclosed
US-11635547-B2 Composition for the manufacture of an ophthalmic lens comprising an encapsulated light-absorbing additive ESSILOR INTERNATIONAL (FR) 2023-04-25 US disclosed
EP-2602654-B1 Ophthalmic filter ESSILOR INT (FR) 2023-04-19 EP disclosed
EP-3497488-B2 OPHTALMIC LENS COMPRISING AN ENCAPSULATED LIGHT-ABSORBING ADDITIVE ESSILOR INT (FR) 2023-03-22 EP disclosed
US-7008937-B2 Porphyrins and metalloporphyrins for inhibiting heme iron uptake FRONTIER SCIENTIFIC, INC. (US) 2006-03-07 US disclosed
US-20050112058-A1 Auger effect-based cancer therapy method BEN-GURION UNIVERSITY OF THE NEGEV (IL) 2005-05-26 US disclosed
US-20040254155-A1 Porphyrins and metalloporphyrins for inhibiting heme iron uptake FRONTIER SCIENTIFIC, INC. 2004-12-16 US disclosed
US-6451531-B1 A FIRST BIOLOGICAL MOIETY SELECTED FROM THE GROUP CONSISTING OF A NUCLEIC ACID, A PEPTIDE NUCLEIC ACID, A PROTEIN, A STEROID AND A CARBOHYDRATE, SAID BIOLOGICAL MOIETY BEARING A 1,2-DIOXETANE PRECURSOR BOUND THERETO, SUCH THAT, UPON TROPIX, INC. 2002-09-17 US disclosed
US-20020106687-A1 Dioxetane labeled probes and detection assays employing the same APPLIED BIOSYSTEMS, INC. 2002-08-08 US disclosed
US-6063574-A Dioxetane labeled probes and detection assays employing the same TROPIX, INC. (US) 2000-05-16 US disclosed
US-5800999-A Dioxetane-precursor-labeled probes and detection assays employing the same TROPIX, INC. (US) 1998-09-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020106687-A1 Dioxetane labeled probes and detection assays employing the same DCLRE1A, DDB1, CYP4X1 TERT 3807/4885ENPP2 3575/4885TOP1 46/4885
US-20050112058-A1 Auger effect-based cancer therapy method LIG4, DNMT1, UNG TERT 1097/4885ENPP2 4691/4885TOP1 36/4885
US-20070248534-A1 Auger effect-based cancer therapy method LIG4, DNMT1, UNG TERT 1097/4885ENPP2 4691/4885TOP1 36/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.