Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL449641 | 0.97 | RNPEP (0.35) | RNPEPALDH1A1TDP1MAPTHPGD | |
| Trifluoroacetic Acid SCHEMBL16394297 | 0.85 | — | — | |
| Trifluoroacetic Acid SCHEMBL3140803 | 0.84 | TP53 (0.44) | ALDH1A1LMNATP53TSHRL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL27714775 | 0.84 | TP53 (0.44) | ALDH1A1LMNATP53TSHRL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL4544068 | 0.83 | — | — | |
| Trifluoroacetic Acid SCHEMBL7793452 | 0.81 | TP53 (0.42) | ALDH1A1LMNATP53TSHRL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL3055318 | 0.81 | ALDH1A1 (0.38) | ALDH1A1LMNATP53TSHRL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL20854191 | 0.81 | ALDH1A1 (0.35) | ALDH1A1HSD17B10TP53TSHRL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL7209644 | 0.81 | ALDH1A1 (0.35) | ALDH1A1TP53TSHRL3MBTL1THRB | |
| Trifluoroacetic Acid SCHEMBL1035693 | 0.81 | TP53 (0.42) | ALDH1A1LMNATP53TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250395-B2 | Especially fused to dihydrofolate reductase, used for treating diseases marked by increased angiogenesis | BEIJING INSTITUTE FOR CANCER RESEARCH (CN) | 2007-07-31 | — | — | US | disclosed |
| US-20050154187-A1 | Especially fused to dihydrofolate reductase, used for treating diseases marked by increased angiogenesis; also polynucleotides encoding the polypeptide and use of the polynucleotides in gene therapy. | BEIJING INSTITUTE FOR CANCER RESEARCH (CN) | 2005-07-14 | — | — | US | disclosed |
| EP-0277561-B1 | NEW ARGININE DERIVATIVE, PROCESS FOR THE PREPARATION THEREOF AND ITS USE IN PEPTIDE SYNTHESIS | ENIRICERCHE S.p.A. (IT) | 1992-04-15 | — | — | EP | disclosed |
| EP-0277561-A1 | New arginine derivative, process for the preparation thereof and its use in peptide synthesis | ENIRICERCHE S.p.A. (IT) | 1988-08-10 | — | — | EP | disclosed |