Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 6/20 | 0.49 |
| ▸ | MDM4 | O15151 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9247661 | 0.91 | MDM2 (0.48) | MDM2MDM4TP53PTPN1CASP3 | |
| SCHEMBL9136556 | 0.89 | MDM2 (0.49) | MDM2MDM4TP53PTPN1CASP3 | |
| SCHEMBL9136558 | 0.89 | MDM2 (0.49) | MDM2MDM4TP53PTPN1CASP3 | |
| SCHEMBL8933064 | 0.88 | MDM2 (0.52) | MDM2MDM4TP53PTPN1CASP3 | |
| SCHEMBL5488292 | 0.87 | MDM4 (0.44) | MDM2MDM4TP53PTPN1CASP3 | |
| SCHEMBL2304920 | 0.86 | MDM2 (0.59) | MDM2MDM4TP53PTPN1CASP3 | |
| SCHEMBL3724885 | 0.86 | MDM2 (0.59) | MDM2MDM4TP53PTPN1CASP3 | |
| SCHEMBL2304915 | 0.86 | MDM2 (0.59) | MDM2MDM4TP53PTPN1CASP3 | |
| SCHEMBL30686153 | 0.86 | MDM2 (0.59) | MDM2MDM4TP53PTPN1CASP3 | |
| SCHEMBL29445591 | 0.86 | MDM2 (0.59) | MDM2MDM4TP53PTPN1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161542-A1 | Ptb1b photoprobes | RAMACHANDRAN CHIDAMBARAM | 2007-07-12 | — | — | US | disclosed |
| WO-2005056582-A1 | PTP1B PHOTOPROBES | MERCK FROSST CANADA LTD. (CA) | 2005-06-23 | — | — | WO | disclosed |
| US-6348572-B1 | TRIPEPTIDE CONTAINING 4-PHOSPHONO(DIFLUOROMETHYL)PHENYLALANINE GROUPS; TYROSINE PHOSPHATASE AND CYSTEINE PROTEASE ASSAYS; COMPETITIVE BINDING; DIABETES, CANCER, ALZHEIMER*S DISEASE, OSTEOPOROSIS | MERCK FROSST CANADA & CO. (CA) | 2002-02-19 | — | — | US | disclosed |
| US-6114132-A | FOR DETERMINING THE BINDING ABILITY OF A LIGAND TO A CYSTEINE-CONTAINING WILD-TYPE TYROSINE PHOSPHATASE; MEDICAL DIAGNOSIS | MERCK FROSST CANADA & CO. (CA) | 2000-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161542-A1 | Ptb1b photoprobes | PTBP1, PTBP3, PPP1R1B | MDM2 2575/4885MDM4 3416/4885TP53 2701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.