Terephthalic Acid

Terephthalic Acid

SCHEMBL5494019

O=C(O)c1ccc(-c2ccccc2)c(C(=O)O)c1-c1ccccc1.O=C(O)c1ccc(C(=O)O)cc1.O=C(O)c1ccccc1

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

OPRM1

The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C8 P10632 3/20 0.47
CYP2C9 P11712 1/20 0.47
DAO P14920 1/20 0.45
TSHR P16473 1/20 0.45
NAPRT Q6XQN6 1/20 0.45
CDC25B P30305 2/20 0.45
ATM Q13315 1/20 0.45
HNF4A P41235 1/20 0.45
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
SRD5A2 P31213 1/20 0.44
KDM4E B2RXH2 1/20 0.44
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
FOLH1 Q04609 3/20 0.42
AKR1C3 P42330 1/20 0.42
CDC25A P30304 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TTR P02766 1/20 0.41
RXRA P19793 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Terephthalic Acid SCHEMBL11120261 0.98 CDC25B (0.46) CYP2C8CYP2C9DAOTSHRNAPRT
SCHEMBL8948605 0.92 FOLH1 (0.47) CYP2C8CYP2C9TSHRCDC25BATM
SCHEMBL995362 0.92 HNF4A (0.52) CYP2C9TSHRCDC25BATMHNF4A
SCHEMBL11802032 0.90 HNF4A (0.50) CYP2C9TSHRCDC25BATMHNF4A
SCHEMBL10626438 0.89 CYP2C8 (0.54) CYP2C8CYP2C9CDC25BATMSRD5A2
Fluorene SCHEMBL5147055 0.87 SRD5A2 (0.55) CYP2C8CYP2C9TSHRCDC25BATM
Benzoic Acid SCHEMBL5568856 0.86 HNF4A (0.47) CYP2C8CYP2C9DAOTSHRNAPRT
SCHEMBL1707625 0.83 NPC1 (0.49) CYP2C8CYP2C9DAOTSHRNAPRT
SCHEMBL10783650 0.83 FOLH1 (0.54) KDM4EFOLH1AKR1C3RXRARXRB
SCHEMBL27734925 0.82 CDC25B (0.50) CYP2C8CYP2C9TSHRCDC25BATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0815876-B1 Instrument sterilization container formed of a liquid crystal polymer ETHICON INC (US) 2003-10-08 EP claimed
US-6379631-B1 FOR MEDICAL EQUIPMENT; POLYESTERS SUCH AS POLYBENZOATE NAPHTHALATE, POLYBENZOATE TEREPHTHALATE BISPHENOL ISOPHTHALATE; HIGH STRENGTH JOHNSON & JOHNSON MEDICAL, INC. 2002-04-30 US claimed
EP-0815876-A2 Instrument sterilization container formed of a liquid crystal polymer JOHNSON & JOHNSON MEDICAL, INC. (US) 1998-01-07 EP claimed
WO-2015107095-A1 POLYMER FILM CEDAR ADVANCED TECHNOLOGY GROUP LTD. (CH) 2015-07-23 WO disclosed
US-7300637-B2 Sterilization container kit ETHICON, INC. (US) 2007-11-27 US disclosed
US-6759017-B2 STERILIZATION ENCLOSURES SEPARATED VERTICALLY BY A STACKING DEVICE THAT ALLOWS DIFFUSION BETWEEN THE ENCLOSURES AND INTO THE ENCLOSURES THROUGH THEIR UPPER AND LOWER FACING PORTIONS. ETHICON, INC. 2004-07-06 US disclosed
US-6692693-B2 A STERILIZATION CONTAINER FOR STERILIZING, STORING AND TRANSPORTING MEDICAL INSTRUMENTS IS FORMED OF A LIQUID CRYSTAL POLYMER, SUCH AS AN AROMATIC POLYESTER ETHICON, INC. 2004-02-17 US disclosed
US-6692693-B2 A STERILIZATION CONTAINER FOR STERILIZING, STORING AND TRANSPORTING MEDICAL INSTRUMENTS IS FORMED OF A LIQUID CRYSTAL POLYMER, SUCH AS AN AROMATIC POLYESTER ETHICON, INC. 2004-02-17 US disclosed
CN-1135118-C Container of LCD polymer for apparatus sterilizing �Ϳ���ҽҩ��˾ 2004-01-21 CN disclosed
US-20030211023-A1 Instrument sterilization container having improved diffusion ETHICON, INC. 2003-11-13 US disclosed
EP-0815876-B1 Instrument sterilization container formed of a liquid crystal polymer ETHICON INC (US) 2003-10-08 EP disclosed
US-6379631-B1 FOR MEDICAL EQUIPMENT; POLYESTERS SUCH AS POLYBENZOATE NAPHTHALATE, POLYBENZOATE TEREPHTHALATE BISPHENOL ISOPHTHALATE; HIGH STRENGTH JOHNSON & JOHNSON MEDICAL, INC. 2002-04-30 US disclosed
US-6264902-B1 STERILIZATION, TRANSPORTATING, STORAGE; RECESSED LATCH JOHNSON & JOHNSON MEDICAL, INC. 2001-07-24 US disclosed
US-6193932-B1 Sterilization container and instrument holder therefor ETHICON, INC. 2001-02-27 US disclosed
EP-0815876-A3 Instrument sterilization container formed of a liquid crystal polymer JOHNSON & JOHNSON MEDICAL, INC. (US) 1999-12-15 EP disclosed
CN-1182624-A Container of LCD polymer for apparatus sterilizing JOHNSON & JOHNSON MEDICAL (US) 1998-05-27 CN disclosed
EP-0815875-A2 Instrument sterilization container having an improved latching mechanism JOHNSON & JOHNSON MEDICAL, INC. (US) 1998-01-07 EP disclosed
EP-0815874-A2 Instrument sterilization container having improved drainage and support for an instrument mat JOHNSON & JOHNSON MEDICAL, INC. (US) 1998-01-07 EP disclosed
EP-0815876-A2 Instrument sterilization container formed of a liquid crystal polymer JOHNSON & JOHNSON MEDICAL, INC. (US) 1998-01-07 EP disclosed
EP-0815876-A2 Instrument sterilization container formed of a liquid crystal polymer JOHNSON & JOHNSON MEDICAL, INC. (US) 1998-01-07 EP disclosed