SCHEMBL8948605

SCHEMBL8948605

O=C(O)c1ccc(-c2ccc(C(=O)O)c(-c3ccc(C(=O)O)cc3)c2C(=O)O)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 2/20 0.47
CYP2C8 P10632 3/20 0.46
TTR P02766 1/20 0.44
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
HDAC9 Q9UKV0 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
TP53 P04637 1/20 0.43
TSHR P16473 1/20 0.43
PTPN11 Q06124 1/20 0.43
RXRA P19793 1/20 0.42
RXRB P28702 1/20 0.42
SRD5A2 P31213 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Terephthalic Acid SCHEMBL11120261 0.93 CDC25B (0.46) FOLH1CYP2C8TTRTP53TSHR
Terephthalic Acid SCHEMBL5494019 0.92 CYP2C8 (0.47) FOLH1CYP2C8TTRTSHRRXRA
SCHEMBL8948670 0.88 FOLH1 (0.38) FOLH1CYP2C8TTRHDAC3HDAC4
SCHEMBL27933474 0.87 TTR (0.48) FOLH1TTRTP53TSHRRXRA
SCHEMBL10787325 0.86 FOLH1 (0.47) FOLH1CYP2C8TTRHDAC3HDAC4
SCHEMBL141962 0.85 FOLH1 (0.50) FOLH1CYP2C8HDAC3HDAC4HDAC1
SCHEMBL27914954 0.85 TTR (0.47) FOLH1TTRTP53TSHRRXRA
SCHEMBL995362 0.85 HNF4A (0.52) FOLH1TSHRCDC25BATMCYP2C9
SCHEMBL10605487 0.84 EGFR (0.50) CYP2C8TSHRATMHSD17B10SMN1; SMN2
SCHEMBL21937379 0.84 BCL2L1 (0.44) TTRBCL2L1BADHSD17B10SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5525699-A Copolymers having a controlled sequence structure HOECHST CELANESE CORP. (US) 1996-06-11 US disclosed
EP-0569930-A2 Copolymers having a controlled sequence structure HOECHST CELANESE CORPORATION (US) 1993-11-18 EP disclosed
US-5256760-A Forming controlled sequence condensation copolymers HOECHST CELANESE CORP. (US) 1993-10-26 US disclosed
EP-0052927-B1 STRETCHED FILM STRUCTURE OF THE POLY-1,3-PHENYLENE TEREPHTHALATE TYPE MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1987-01-07 EP disclosed
US-4390683-A Stretched film structure of the poly-1,3-phenylene terephthalate type MITSUI PETROCHEMICAL INDUSTRIES LTD. (JP) 1983-06-28 US disclosed