Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPY1R | P25929 | 10/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13452426 | 0.85 | SLC6A2 (0.53) | EEDTP53CYP3A4MAP2K1 | |
| SCHEMBL4462919 | 0.84 | NFE2L2 (0.57) | NPY1RKMT2AHRH3NFE2L2 | |
| SCHEMBL11715794 | 0.83 | NPY1R (0.42) | EEDNPY1RACP1 | |
| SCHEMBL6632458 | 0.81 | EED (0.44) | EEDNPY1RACP1KMT2AMAP2K1 | |
| SCHEMBL6932722 | 0.81 | NPY1R (0.46) | EEDNPY1RHRH3 | |
| SCHEMBL11715754 | 0.81 | EED (0.40) | EEDNPY1RACP1KMT2A | |
| SCHEMBL8971574 | 0.80 | EED (0.46) | EEDNPY1RACP1CYP3A4KMT2A | |
| SCHEMBL11715735 | 0.79 | KMT2A (0.45) | EEDNPY1RACP1KMT2AHRH3 | |
| SCHEMBL30556335 | 0.78 | ACP1 (0.47) | EEDNPY1RACP1 | |
| SCHEMBL5188095 | 0.78 | ACP1 (0.55) | EEDACP1CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | disclosed |