Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 6/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
| ▸ | PTPRE | P23469 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 3/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14403446 | 0.86 | GPR84 (0.43) | GPR84KIF11AHRPTPRCPTPN2 | |
| SCHEMBL28777719 | 0.83 | GPR84 (0.54) | GPR84KIF11AHRESR1CTNNB1 | |
| SCHEMBL5236426 | 0.78 | GPR84 (0.64) | GPR84KIF11AHRESR1CTNNB1 | |
| SCHEMBL12288155 | 0.76 | GPR84 (0.47) | GPR84KIF11AHRESR1CTNNB1 | |
| SCHEMBL2272066 | 0.76 | CSNK2A1 (0.55) | GPR84KIF11AHRESR1CTNNB1 | |
| SCHEMBL395515 | 0.76 | GPR84 (0.47) | GPR84KIF11AHRESR1CTNNB1 | |
| SCHEMBL5495155 | 0.76 | GPR84 (0.47) | GPR84KIF11AHRESR1CTNNB1 | |
| SCHEMBL8957501 | 0.75 | GPR84 (0.46) | GPR84KIF11AHRESR1CTNNB1 | |
| SCHEMBL17703916 | 0.74 | GPR84 (0.64) | GPR84KIF11AHRESR1CTNNB1 | |
| SCHEMBL850198 | 0.73 | CSNK2A1 (0.55) | GPR84KIF11AHRESR1CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773816-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006002421-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-01-05 | — | — | WO | disclosed |