Sugi Predict

Sugi Predict / Compounds / SCHEMBL850198

SCHEMBL850198

SCHEMBL850198

FC(F)(F)c1cc2[nH]ccc2cc1Br

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CSNK2A1 P68400 1/20 0.55
▸ GPR84 Q9NQS5 1/20 0.47
▸ AHR P35869 6/20 0.46
▸ CYP2A6 P11509 2/20 0.46
▸ NR4A2 P43354 2/20 0.46
▸ KIF11 P52732 1/20 0.44
▸ CTNNB1 P35222 1/20 0.39
▸ WNT3A P56704 1/20 0.39
▸ S1PR1 P21453 1/20 0.38
▸ CMA1 P23946 1/20 0.37
▸ F7 P08709 1/20 0.37
▸ LTA4H P09960 1/20 0.37
▸ F3 P13726 1/20 0.37
▸ TYR P14679 1/20 0.37
▸ USP2 O75604 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ ALOX15 P16050 1/20 0.37
▸ RAD51 Q06609 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ ESR1 P03372 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28777719 0.84 GPR84 (0.54) CSNK2A1GPR84AHRCYP2A6NR4A2
SCHEMBL17703916 0.79 GPR84 (0.64) CSNK2A1GPR84AHRCYP2A6NR4A2
SCHEMBL22438351 0.78 CSNK2A1 (0.50) CSNK2A1GPR84AHRNR4A2KIF11
SCHEMBL3497908 0.78 GPR84 (0.47) CSNK2A1GPR84AHRCYP2A6NR4A2
SCHEMBL3334627 0.78 GPR84 (0.47) CSNK2A1GPR84AHRCYP2A6NR4A2
SCHEMBL23932310 0.78 CSNK2A1 (0.69) CSNK2A1GPR84AHRCYP2A6NR4A2
SCHEMBL8957501 0.76 GPR84 (0.46) CSNK2A1GPR84AHRCYP2A6NR4A2
SCHEMBL5236426 0.76 GPR84 (0.64) CSNK2A1GPR84AHRCYP2A6NR4A2
SCHEMBL1565699 0.75 GPR84 (0.69) CSNK2A1GPR84AHRCYP2A6NR4A2
SCHEMBL849501 0.75 CSNK2A1 (0.60) CSNK2A1GPR84AHRCYP2A6NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11352352-B2 Aminopyrimidine compound, preparation method therefor and use thereof Beijing Adamadle Biotechnology Limited Liability Company (CN) 2022-06-07 — — US disclosed
EP-3640248-A1 AMINOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF Beijing Adamadle Biotechnology Limited Liability Company (CN) 2020-04-22 — — EP disclosed
US-20200087296-A1 AMINOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF Beijing Adamadle Biotechnology Limited Liability Company (CN) 2020-03-19 — — US disclosed
EP-3027608-B1 SUBSTITUTED PYRIDINE-PIPERAZINYL ANALOGUES AS RSV ANTIVIRAL COMPOUNDS JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) 2019-02-20 — — EP disclosed
US-10150761-B2 Substituted pyridine-piperazinyl analogues as RSV antiviral compounds JANSSEN SCIENCES IRELAND UC (IE) 2018-12-11 — — US disclosed
CN-105683183-B The pyridine being substituted-piperazinyl analog as RSV antiviral compounds 爱尔兰詹森科学公司 2018-06-22 — — CN disclosed
US-20170291891-A1 SUBSTITUTED PYRIDINE-PIPERAZINYL ANALOGUES AS RSV ANTIVIRAL COMPOUNDS JANSSEN SCIENCES IRELAND UC (IE) 2017-10-12 — — US disclosed
US-9487517-B2 Spiroimidazolone derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-11-08 — — US disclosed
US-9487517-B2 Spiroimidazolone derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-11-08 — — US disclosed
US-9487517-B2 Spiroimidazolone derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-11-08 — — US disclosed
US-9169254-B2 Spiroimidazolone derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-10-27 — — US disclosed
US-9169254-B2 Spiroimidazolone derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-10-27 — — US disclosed
WO-2015014836-A1 SUBSTITUTED PYRIDINE-PIPERAZINYL ANALOGUES AS RSV ANTIVIRAL COMPOUNDS JANSSEN R&D IRELAND (IE) 2015-02-05 — — WO disclosed
EP-2433940-B1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 2014-09-24 — — EP disclosed
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-10-25 — — US disclosed
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-10-25 — — US disclosed
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-10-25 — — US disclosed
EP-2433940-A1 SPIROIMIDAZOLONE DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 2012-03-28 — — EP disclosed
EP-2433940-A1 SPIROIMIDAZOLONE DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 2012-03-28 — — EP disclosed
WO-2010126030-A1 SPIROIMIDAZOLONE DERIVATIVE 中外製薬株式会社 (JP) 2010-11-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE WNK3, REN, SGK3 CSNK2A1 411/4885GPR84 1672/4885AHR 3554/4885
US-20170291891-A1 SUBSTITUTED PYRIDINE-PIPERAZINYL ANALOGUES AS RSV ANTIVIRAL COMPOUNDS MAVS, ZC3HAV1, PIR CSNK2A1 2577/4885GPR84 1293/4885AHR 397/4885
US-10150761-B2 Substituted pyridine-piperazinyl analogues as RSV antiviral compounds MAVS, ZC3HAV1, PIR CSNK2A1 2606/4885GPR84 1340/4885AHR 395/4885
US-20200087296-A1 AMINOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF WEE1, WEE2, EGFR CSNK2A1 2230/4885GPR84 3363/4885AHR 1236/4885
US-11352352-B2 Aminopyrimidine compound, preparation method therefor and use thereof WEE1, WEE2, EGFR CSNK2A1 2230/4885GPR84 3363/4885AHR 1236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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