Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.54 |
| ▸ | CTSB | P07858 | 2/20 | 0.54 |
| ▸ | CTSK | P43235 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2303341 | 0.77 | HDAC3 (0.64) | CTSLCTSBCTSKGAASMN1; SMN2 | |
| SCHEMBL30426179 | 0.76 | CTSL (0.57) | CTSLCTSBCTSKGAASMN1; SMN2 | |
| SCHEMBL2356975 | 0.75 | CTSL (0.49) | CTSLCTSBCTSKGAASMN1; SMN2 | |
| SCHEMBL31414557 | 0.74 | HPGD (0.47) | CTSLCTSBCTSKGAASMN1; SMN2 | |
| SCHEMBL1116600 | 0.74 | TDP1 (0.53) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL4956356 | 0.74 | CTSL (0.59) | CTSLCTSBCTSKGAASMN1; SMN2 | |
| SCHEMBL8393362 | 0.74 | SMN1; SMN2 (0.68) | CTSLCTSBCTSKGAASMN1; SMN2 | |
| SCHEMBL963468 | 0.74 | HPGD (0.70) | CTSLCTSBCTSKGAASMN1; SMN2 | |
| SCHEMBL6154041 | 0.74 | HPGD (0.70) | CTSLCTSBCTSKGAASMN1; SMN2 | |
| SCHEMBL10353965 | 0.74 | OPRM1 (0.58) | CTSLCTSBCTSKGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786814-A1 | BICYCLONONENE DERIVATIVES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006021402-A1 | BICYCLONONENE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2006-03-02 | — | — | WO | disclosed |