Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 6/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2765348 | 1.00 | ADAMTS5 (0.59) | ADAMTS5CYP2C19MAPK1SLC1A3SLC1A2 | |
| SCHEMBL2765349 | 1.00 | ADAMTS5 (0.59) | ADAMTS5CYP2C19MAPK1SLC1A3SLC1A2 | |
| SCHEMBL2765675 | 0.81 | ADAMTS5 (0.69) | ADAMTS5CYP2C19MAPK1ALDH1A1 | |
| SCHEMBL2765671 | 0.81 | ADAMTS5 (0.69) | ADAMTS5CYP2C19MAPK1ALDH1A1 | |
| SCHEMBL5494344 | 0.81 | ADAMTS5 (0.69) | ADAMTS5CYP2C19MAPK1ALDH1A1 | |
| SCHEMBL5492303 | 0.80 | ADAMTS5 (0.66) | ADAMTS5CYP2C19MAPK1 | |
| SCHEMBL2763926 | 0.80 | ADAMTS5 (0.66) | ADAMTS5CYP2C19MAPK1ALDH1A1MEN1 | |
| SCHEMBL2763988 | 0.80 | ADAMTS5 (0.66) | ADAMTS5CYP2C19MAPK1 | |
| SCHEMBL2765101 | 0.80 | ADAMTS5 (0.66) | ADAMTS5CYP2C19MAPK1ALDH1A1MEN1 | |
| SCHEMBL2763922 | 0.80 | ADAMTS5 (0.66) | ADAMTS5CYP2C19MAPK1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007516982-A | — | — | 2007-06-28 | — | — | JP | claimed |
| EP-1694410-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | Japan Tobacco, Inc. (JP) | 2006-08-30 | — | — | EP | claimed |
| WO-2005058884-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-06-30 | — | — | WO | claimed |