Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303596 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBLMNAS1PR5ALDH1A1 | |
| SCHEMBL2357857 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBLMNAS1PR5ALDH1A1 | |
| SCHEMBL2345851 | 0.91 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBLMNAS1PR5ALDH1A1 | |
| SCHEMBL28253726 | 0.91 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBLMNAS1PR5ALDH1A1 | |
| SCHEMBL14159621 | 0.91 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBLMNAS1PR5ALDH1A1 | |
| SCHEMBL4129800 | 0.91 | ALDH1A1 (0.48) | SMN1; SMN2LMNAS1PR5ALDH1A1GRM3 | |
| SCHEMBL15322064 | 0.87 | ALDH1A1 (0.55) | SMN1; SMN2POLBLMNAALDH1A1KMT2A | |
| SCHEMBL6197818 | 0.86 | ALDH1A1 (0.59) | SMN1; SMN2POLBALDH1A1CYP1A2GAA | |
| SCHEMBL1841156 | 0.86 | ALDH1A1 (0.59) | SMN1; SMN2POLBALDH1A1CYP1A2GAA | |
| SCHEMBL27926602 | 0.86 | ALDH1A1 (0.60) | SMN1; SMN2POLBALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844022-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | Hanmi Pharm. Co., Ltd. (KR) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006071017-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2006-07-06 | — | — | WO | disclosed |