Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1841156 | 1.00 | ALDH1A1 (0.59) | ALDH1A1GAAHTTTHRBATM | |
| SCHEMBL9214032 | 0.90 | GAA (0.62) | ALDH1A1GAAHTTTHRBATM | |
| SCHEMBL4129800 | 0.89 | ALDH1A1 (0.48) | ALDH1A1GAAHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL6215242 | 0.87 | ALDH1A1 (0.71) | ALDH1A1HTTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL5495665 | 0.86 | SMN1; SMN2 (0.49) | ALDH1A1GAAHTTSMN1; SMN2HPGD | |
| SCHEMBL2357857 | 0.86 | SMN1; SMN2 (0.49) | ALDH1A1GAAHTTSMN1; SMN2HPGD | |
| SCHEMBL8303596 | 0.86 | SMN1; SMN2 (0.49) | ALDH1A1GAAHTTSMN1; SMN2HPGD | |
| SCHEMBL26626591 | 0.83 | GRM3 (0.48) | ALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL1420981 | 0.83 | GRM3 (0.48) | ALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL26626619 | 0.83 | GRM3 (0.48) | ALDH1A1HTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597256-A1 | N-HETEROCYCLYL-SUBSTITUTED AMINO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PFIZER INC. (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004074283-A1 | N-HETEROCYCLYL-SUBSTITUTED AMINO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PFIZER INC. (US) | 2004-09-02 | — | — | WO | disclosed |