Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.46 |
| ▸ | PGK2 | P07205 | 1/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.43 |
| ▸ | PGD | P52209 | 3/20 | 0.43 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.43 |
| ▸ | LPAR4 | Q99677 | 2/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.43 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.43 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL27698615 | 0.88 | PGK1 (0.50) | PGK1PGK2LPAR1PGDLPAR5 | |
| Phosphoric Acid SCHEMBL2571849 | 0.88 | PGK1 (0.50) | PGK1PGK2LPAR1PGDLPAR5 | |
| Glycerin SCHEMBL28247436 | 0.86 | PGK1 (0.48) | PGK1PGK2LPAR1PGDLPAR5 | |
| SCHEMBL14278847 | 0.86 | PGK1 (0.52) | PGK1PGK2LPAR1PGDLPAR5 | |
| SCHEMBL14278848 | 0.86 | PGK1 (0.52) | PGK1PGK2LPAR1PGDLPAR5 | |
| SCHEMBL7341 | 0.86 | PGK1 (0.52) | PGK1PGK2LPAR1PGDLPAR5 | |
| SCHEMBL7340 | 0.86 | PGK1 (0.52) | PGK1PGK2LPAR1PGDLPAR5 | |
| SCHEMBL6655023 | 0.86 | PGK1 (0.52) | PGK1PGK2LPAR1PGDLPAR5 | |
| SCHEMBL213379 | 0.86 | PGK1 (0.52) | PGK1PGK2LPAR1PGDLPAR5 | |
| Alcohol SCHEMBL28123008 | 0.84 | LPAR5 (0.51) | PGK1PGK2LPAR1PGDLPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202512-B2 | Metabolic uncoupling therapy | MCCLEARY EDWARD LARRY (US) | 2012-06-19 | — | — | US | disclosed |
| US-20070160590-A1 | Metabolic uncoupling therapy | MCCLEARY EDWARD L | 2007-07-12 | — | — | US | disclosed |
| US-20040043013-A1 | Metabolic uncoupling therapy | MCCLEARY EDWARD LARRY (US) | 2004-03-04 | — | — | US | disclosed |