Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 18/20 | 0.58 |
| ▸ | KIT | P10721 | 18/20 | 0.58 |
| ▸ | BCR | P11274 | 6/20 | 0.58 |
| ▸ | ABL2 | P42684 | 14/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.57 |
| ▸ | EGFR | P00533 | 3/20 | 0.57 |
| ▸ | BRAF | P15056 | 3/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | FYN | P06241 | 2/20 | 0.57 |
| ▸ | CSF1R | P07333 | 2/20 | 0.57 |
| ▸ | LYN | P07948 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | FGR | P09769 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | NQO2 | P16083 | 2/20 | 0.57 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.57 |
| ▸ | FRK | P42685 | 2/20 | 0.57 |
| ▸ | BLK | P51451 | 2/20 | 0.57 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499264 | 0.89 | ABL1 (0.52) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL5500661 | 0.87 | ABL1 (0.64) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL3857811 | 0.76 | ABL1 (0.85) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL29198404 | 0.74 | ABL1 (0.74) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL4282281 | 0.74 | ABL1 (0.78) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL3860049 | 0.74 | ABL1 (0.85) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL5496170 | 0.74 | MGLL (0.48) | KITPDGFRBLMNAKDR | |
| SCHEMBL11939618 | 0.74 | ABL1 (1.00) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL12420434 | 0.73 | ABL1 (0.77) | ABL1KITBCRABL2PDGFRA | |
| SCHEMBL4841459 | 0.73 | ABL1 (0.84) | ABL1KITBCRABL2PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | claimed |
| EP-1753750-A1 | THIOPHENE HETEROARYL AMINES | Sugen, Inc. (US) | 2007-02-21 | — | — | EP | claimed |
| WO-2005113548-A1 | THIOPHENE HETEROARYL AMINES | SUGEN, INC. (US) | 2005-12-01 | — | — | WO | claimed |
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | disclosed |
| EP-1753750-A1 | THIOPHENE HETEROARYL AMINES | Sugen, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005113548-A1 | THIOPHENE HETEROARYL AMINES | SUGEN, INC. (US) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293484-A1 | Thiophene Heteroaryl Amines | TTK, CHEK2, ABL1 | ABL1 3/4885KIT 1845/4885BCR 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.