Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.52 |
| ▸ | BCR | P11274 | 5/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 3/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | KIT | P10721 | 9/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 4/20 | 0.51 |
| ▸ | CSF1R | P07333 | 4/20 | 0.51 |
| ▸ | ABL2 | P42684 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.51 |
| ▸ | FYN | P06241 | 2/20 | 0.51 |
| ▸ | LYN | P07948 | 2/20 | 0.51 |
| ▸ | FGR | P09769 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | NQO2 | P16083 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500661 | 0.91 | ABL1 (0.64) | ABL1BCRPDGFRAPDGFRBSRC | |
| SCHEMBL5495979 | 0.89 | ABL1 (0.58) | ABL1BCRPDGFRAPDGFRBSRC | |
| SCHEMBL5496170 | 0.82 | MGLL (0.48) | PDGFRBKITKDRLMNAHDAC6 | |
| SCHEMBL5495338 | 0.79 | KDM4E (0.47) | ABL1BCRPDGFRAPDGFRBMAPK14 | |
| SCHEMBL5499926 | 0.79 | POLB (0.51) | ABL1PDGFRBKDRCA12CA1 | |
| SCHEMBL4901725 | 0.77 | ABL1 (0.72) | ABL1BCRPDGFRAPDGFRBSRC | |
| SCHEMBL29836713 | 0.77 | SRC (0.57) | ABL1BCRPDGFRAPDGFRBSRC | |
| SCHEMBL4902292 | 0.76 | ABL1 (0.86) | ABL1BCRPDGFRAPDGFRBSRC | |
| SCHEMBL24024030 | 0.75 | RAB9A (0.73) | BTKHDAC6 | |
| SCHEMBL14845834 | 0.75 | BTK (0.67) | MAPK14LMNABTKHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | claimed |
| EP-1753750-A1 | THIOPHENE HETEROARYL AMINES | Sugen, Inc. (US) | 2007-02-21 | — | — | EP | claimed |
| WO-2005113548-A1 | THIOPHENE HETEROARYL AMINES | SUGEN, INC. (US) | 2005-12-01 | — | — | WO | claimed |
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | disclosed |
| EP-1753750-A1 | THIOPHENE HETEROARYL AMINES | Sugen, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005113548-A1 | THIOPHENE HETEROARYL AMINES | SUGEN, INC. (US) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293484-A1 | Thiophene Heteroaryl Amines | TTK, CHEK2, ABL1 | ABL1 3/4885BCR 1003/4885PDGFRA 859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.