SCHEMBL5496562

SCHEMBL5496562

CC(Oc1ccc(SCCC#Cc2ccc(C(F)(F)F)cc2)cc1)C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 13/20 0.52
PPARA Q07869 3/20 0.52
PPARG P37231 3/20 0.40
SLC6A4 P31645 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
CYP1A2 P05177 1/20 0.38
GAA P10253 1/20 0.38
CYP2C9 P11712 1/20 0.38
PKM P14618 1/20 0.38
CYP2C19 P33261 1/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5504301 0.83 ACACB (0.41) PPARDPPARAPPARGSLC6A4CYP1A2
SCHEMBL10944856 0.78 PPARA (0.56) PPARDPPARAPPARGCYP1A2GAA
SCHEMBL11597291 0.77 CYP1A2 (0.59) PPARDPPARAPPARGCYP1A2GAA
SCHEMBL21057241 0.77 CYP1A2 (0.59) PPARDPPARAPPARGCYP1A2GAA
SCHEMBL25212758 0.77 CYP1A2 (0.59) PPARDPPARAPPARGCYP1A2GAA
SCHEMBL5501943 0.75 PPARG (0.47) PPARDPPARAPPARGCYP1A2GAA
SCHEMBL5629870 0.74 PPARD (0.63) PPARDPPARAPPARG
SCHEMBL5497621 0.74 EPHX2 (0.46) PPARDPPARAPPARGCYP1A2GAA
SCHEMBL5974763 0.73 PPARD (0.52) PPARDPPARA
SCHEMBL136831 0.73 CYP1A2 (0.54) PPARDPPARAPPARGCYP1A2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1765760-A1 PHENYL DERIVATIVES COMPRISING AN ACETYLENE GROUP F.HOFFMANN-LA ROCHE AG (CH) 2007-03-28 EP disclosed
WO-2006002802-A1 PHENYL DERIVATIVES COMPRISING AN ACETYLENE GROUP F. HOFFMANN-LA ROCHE AG (CH) 2006-01-12 WO disclosed