SCHEMBL5501943

SCHEMBL5501943

CC(Oc1ccc(OCCCC#Cc2ccc(OC(F)(F)F)cc2)cc1)C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 3/20 0.47
PPARA Q07869 3/20 0.47
PPARD Q03181 2/20 0.47
ACACB O00763 2/20 0.45
CYP2C9 P11712 2/20 0.40
CYP1A2 P05177 1/20 0.40
GAA P10253 1/20 0.40
PKM P14618 1/20 0.40
CYP2C19 P33261 1/20 0.40
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5504301 0.88 ACACB (0.41) PPARGPPARAPPARDACACBCYP2C9
SCHEMBL3072202 0.80 CYP2C9 (0.59) PPARGPPARACYP2C9CYP1A2GAA
SCHEMBL1378767 0.77 MCL1 (0.42) PPARGPPARAPPARDACACBNTRK1
SCHEMBL1377425 0.77 PPARD (0.42) PPARGPPARAPPARDACACBFFAR1
SCHEMBL11304140 0.76 CYP2C9 (0.54) PPARGPPARACYP2C9CYP1A2GAA
SCHEMBL5489752 0.75 PPARD (0.58) PPARGPPARAPPARD
SCHEMBL5496562 0.75 PPARD (0.52) PPARGPPARAPPARDCYP2C9CYP1A2
SCHEMBL5487844 0.75 PPARD (0.53) PPARGPPARAPPARDFFAR4
SCHEMBL25170018 0.74 FFAR1 (0.50) ACACBCYP2C9CYP1A2CYP2C19HDAC1
SCHEMBL16922731 0.74 ACACB (0.42) ACACBCYP2C9CYP1A2CYP2C19HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1765760-A1 PHENYL DERIVATIVES COMPRISING AN ACETYLENE GROUP F.HOFFMANN-LA ROCHE AG (CH) 2007-03-28 EP disclosed
WO-2006002802-A1 PHENYL DERIVATIVES COMPRISING AN ACETYLENE GROUP F. HOFFMANN-LA ROCHE AG (CH) 2006-01-12 WO disclosed