Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | FPR2 | P25090 | 2/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613640 | 0.99 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1CCR3SLC18A3SLC6A2 | |
| SCHEMBL6304036 | 0.88 | SIGMAR1 (0.58) | SIGMAR1ALDH1A1CCR3SLC18A3POLB | |
| SCHEMBL6304033 | 0.88 | SIGMAR1 (0.58) | SIGMAR1ALDH1A1CCR3SLC18A3POLB | |
| SCHEMBL6310906 | 0.87 | CHRNA7 (0.48) | SIGMAR1ALDH1A1 | |
| SCHEMBL6310911 | 0.87 | CHRNA7 (0.48) | SIGMAR1ALDH1A1 | |
| SCHEMBL6310636 | 0.86 | MCOLN2 (0.48) | ALDH1A1CCR3SLC18A3SLC6A2SLC6A3 | |
| SCHEMBL6310642 | 0.86 | MCOLN2 (0.48) | ALDH1A1CCR3SLC18A3SLC6A2SLC6A3 | |
| SCHEMBL6312662 | 0.86 | EPHX1 (0.52) | SIGMAR1ALDH1A1CCR3SLC18A3POLB | |
| SCHEMBL5499358 | 0.86 | EPHX1 (0.52) | SIGMAR1ALDH1A1CCR3SLC18A3POLB | |
| SCHEMBL6307066 | 0.85 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1CCR3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453804-B1 | CCR-3 RECEPTOR ANTAGONISTS VII | HOFFMANN LA ROCHE (CH) | 2007-08-22 | — | — | EP | claimed |