Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550413 | 1.00 | HSD11B1 (0.38) | HSD11B1FFAR4NPY5RHRH3RIPK1 | |
| SCHEMBL550412 | 1.00 | HSD11B1 (0.38) | HSD11B1FFAR4NPY5RHRH3RIPK1 | |
| SCHEMBL549770 | 1.00 | HSD11B1 (0.38) | HSD11B1FFAR4NPY5RHRH3RIPK1 | |
| SCHEMBL2701197 | 1.00 | HSD11B1 (0.38) | HSD11B1FFAR4NPY5RHRH3RIPK1 | |
| SCHEMBL2701199 | 1.00 | HSD11B1 (0.38) | HSD11B1FFAR4NPY5RHRH3RIPK1 | |
| SCHEMBL4570202 | 0.92 | FFAR4 (0.43) | HSD11B1FFAR4HRH3 | |
| SCHEMBL2698314 | 0.90 | FFAR4 (0.45) | HSD11B1FFAR4 | |
| SCHEMBL551029 | 0.90 | FFAR4 (0.45) | HSD11B1FFAR4 | |
| SCHEMBL550700 | 0.90 | FFAR4 (0.45) | HSD11B1FFAR4 | |
| SCHEMBL550699 | 0.90 | FFAR4 (0.45) | HSD11B1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |