Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706615 | 1.00 | HTR7 (0.46) | HTR7HSD11B1POLBNOTUMNR5A2 | |
| SCHEMBL549779 | 1.00 | HTR7 (0.46) | HTR7HSD11B1POLBNOTUMNR5A2 | |
| SCHEMBL2702594 | 1.00 | HTR7 (0.46) | HTR7HSD11B1POLBNOTUMNR5A2 | |
| SCHEMBL550999 | 1.00 | HTR7 (0.46) | HTR7HSD11B1POLBNOTUMNR5A2 | |
| SCHEMBL2702591 | 1.00 | HTR7 (0.46) | HTR7HSD11B1POLBNOTUMNR5A2 | |
| SCHEMBL549281 | 0.87 | HSD11B1 (0.43) | HTR7HSD11B1NOTUM | |
| SCHEMBL549280 | 0.87 | HSD11B1 (0.43) | HTR7HSD11B1NOTUM | |
| SCHEMBL549196 | 0.87 | POLB (0.50) | HTR7POLBALDH1A1MAPTLMNA | |
| SCHEMBL17082141 | 0.87 | POLB (0.50) | HTR7POLBALDH1A1MAPTLMNA | |
| SCHEMBL549195 | 0.87 | POLB (0.50) | HTR7POLBALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |