Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.41 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14595889 | 0.82 | ERN1 (0.44) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL1185262 | 0.81 | ALDH1A1 (0.59) | ERN1ALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL5501642 | 0.76 | TAAR1 (0.51) | MAPT | |
| SCHEMBL5288675 | 0.76 | NPC1 (0.46) | ALDH1A1KDM4EHPGDLMNAGAA | |
| SCHEMBL692277 | 0.76 | ALDH1A1 (0.57) | ERN1ALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL31631787 | 0.76 | ALDH1A1 (0.57) | ERN1ALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL18570622 | 0.76 | SCN8A (0.46) | ERN1ALDH1A1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL5457539 | 0.75 | TAAR1 (0.50) | — | |
| SCHEMBL5501635 | 0.75 | SLC6A4 (0.58) | MAPT | |
| SCHEMBL15917655 | 0.75 | SCN8A (0.47) | ERN1ALDH1A1KDM4ETSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791807-A1 | THERAPEUTIC DIPHENYL ETHER LIGANDS | Pfizer Products Incorporated (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2007010350-A1 | SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS | PFIZER PRODUCTS INC. (US) | 2007-01-25 | — | — | WO | disclosed |
| US-20070021634-A1 | SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS | PFIZER INC | 2007-01-25 | — | — | US | disclosed |
| US-20070021634-A1 | SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS | PFIZER INC | 2007-01-25 | — | — | US | disclosed |
| WO-2006027684-A1 | THERAPEUTIC DIPHENYL ETHER LIGANDS | PFIZER PRODUCTS INC. (US) | 2006-03-16 | — | — | WO | disclosed |
| US-20060058361-A1 | Therapeutic diphenyl ether ligands | PFIZER INC | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021634-A1 | SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS | DHFR, CYP2F1, EPOR | ERN1 1062/4885TLR2 1988/4885TLR1 3045/4885 |
| US-20060058361-A1 | Therapeutic diphenyl ether ligands | HTR2B, HTR2C, HTR3B | ERN1 4816/4885TLR2 121/4885TLR1 503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.