Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6543695 | 0.99 | PLAU (0.39) | PLAUHPNITGB3ITGA2BSPHK1 | |
| SCHEMBL5502070 | 0.96 | ITGB3 (0.41) | PLAUHPNITGB3ITGA2BSPHK1 | |
| Hydrochloric Acid SCHEMBL6544381 | 0.95 | ITGB3 (0.40) | PLAUHPNITGB3ITGA2BSPHK1 | |
| SCHEMBL5499067 | 0.82 | F10 (0.42) | PLAUHPN | |
| Hydrochloric Acid SCHEMBL6544447 | 0.81 | F10 (0.42) | PLAUHPN | |
| SCHEMBL308627 | 0.80 | F2 (0.38) | PLAUHPNHDAC1CA2CA1 | |
| SCHEMBL4359370 | 0.80 | F2 (0.38) | PLAUHPNHDAC1CA2CA1 | |
| Hydrochloric Acid SCHEMBL308853 | 0.80 | F10 (0.37) | PLAUHPNCA2CA1CA9 | |
| SCHEMBL5494187 | 0.78 | F7 (0.46) | HDAC1 | |
| Hydrochloric Acid SCHEMBL307960 | 0.77 | F7 (0.45) | HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453852-B1 | SELECTIVE UROKINASE INHIBITORS | WILEX AG (DE) | 2007-01-17 | — | — | EP | disclosed |
| EP-1453852-A2 | SELECTIVE UROKINASE INHIBITORS | Wilex AG (DE) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003053999-A2 | SELECTIVE ARYLGUANIDINE PEPTIDES AS UROKINASE INHIBITORS | WILEX AG (DE) | 2003-07-03 | — | — | WO | disclosed |