SCHEMBL5498766

SCHEMBL5498766

CC(=O)C1NC(C(=O)O)C(C)(C)S1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13435199 1.00
SCHEMBL5870085 0.88 ARG1 (0.31)
SCHEMBL5617760 0.75
SCHEMBL23115271 0.75 POLB (0.30)
SCHEMBL28875199 0.75
SCHEMBL8701041 0.73
SCHEMBL11391091 0.71 USP2 (0.31)
SCHEMBL3485597 0.71
SCHEMBL7552953 0.71 MEN1 (0.30)
SCHEMBL24446257 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1272843-B1 METHOD FOR IDENTIFYING REGULATORS OF PROTEIN-AGE FORMATION NIADYNE CORP (US) 2007-06-20 EP disclosed
CN-1205480-C Method for identifying regulators of protein-AGE formation NLADYNE CORP (US) 2005-06-08 CN disclosed
EP-1274418-A4 METHODS OF USE OF PENICILLAMINES FOR THE TREATMENT OF CONDITIONS RESULTING FROM DNA DAMAGE NIADYNE CORP (US) 2005-02-09 EP disclosed
US-6716635-B2 MIXING A SUBSTANCE TO BE TESTED, A HISTONE H1 AND ADP-RIBOSE AND MEASURING THE FLUORESCENCE AND PROTEIN CROSSLINKING; COMBINATORIAL LIBRARIES; ANTIDIABETIC AGENTS; ATHEROSCLEROSIS, CHRONIC NEURODEGENERATIVE DISEASES, E.G.,ALZHEIMER'S; UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION 2004-04-06 US disclosed
CN-1451096-A Method for identifying regulators of protein-AGE formation NIADYNE CORP (US) 2003-10-22 CN disclosed
EP-1274418-A1 METHODS OF USE OF PENICILLAMINES FOR THE TREATMENT OF CONDITIONS RESULTING FROM DNA DAMAGE Niadyne Corporation (US) 2003-01-15 EP disclosed
EP-1272843-A2 METHOD FOR IDENTIFYING REGULATORS OF PROTEIN-AGE FORMATION Niadyne Corporation (US) 2003-01-08 EP disclosed
US-20020156134-A1 Method and use of alpha-amino-beta-mercapto-ethane derivatives as dicarbonyl scavengers for treatment of conditions resulting from protein, lipid, and DNA damage JACOBSON ELAINE L (US) 2002-10-24 US disclosed
US-6417235-B2 INHIBITING PRODUCTION OF ADVANCED GLYCOSYLATION END PRODUCTS IN A PATIENT COMPRISING ADMINISTERING TO THE PATIENT D-PENICILLAMINE, L-PENICILLAMINE, AND D,L-PENICILLAMINE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION 2002-07-09 US disclosed
US-20020037496-A1 Method for identifying regulators of protein-advanced glycation end product (protein-AGE) formation NIADYNE, INC. 2002-03-28 US disclosed
US-20010051658-A1 Method and use of penicillamines and other alpha-amino-beta,beta-mercapto-beta,beta-dimethyl-ethane derivatives as dicarbonyl scavengers for treatment of conditions resulting from protein, lipid, and DNA damage NIADYNE, INC. 2001-12-13 US disclosed
WO-2001078718-A1 METHODS OF USE OF PENICILLAMINES FOR THE TREATMENT OF CONDITIONS RESULTING FROM DNA DAMAGE NIADYNE CORPORATION (US) 2001-10-25 WO disclosed
WO-2001079842-A2 METHOD FOR IDENTIFYING REGULATORS OF PROTEIN-AGE FORMATION NIADYNE CORPORATION (US) 2001-10-25 WO disclosed