Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.45 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 4/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025116 | 0.94 | EHMT2 (0.52) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5218230 | 0.94 | EHMT2 (0.49) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5498950 | 0.92 | EHMT2 (0.54) | EGFRKDRFGFR1FLT1EHMT2 | |
| SCHEMBL4380551 | 0.91 | EHMT2 (0.53) | EGFRKDRFGFR1FLT1RET | |
| SCHEMBL7211058 | 0.89 | PDGFRB (0.47) | EGFRKDRFGFR1FLT1PDGFRB | |
| SCHEMBL7209967 | 0.89 | KDR (0.52) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL4686452 | 0.86 | EHMT2 (0.61) | KDREHMT2EHMT1TLR7TLR9 | |
| SCHEMBL2924579 | 0.85 | EHMT2 (0.60) | KDREHMT2EHMT1TLR7TLR9 | |
| SCHEMBL4374810 | 0.85 | RET (0.51) | KDRRETEHMT2EHMT1TLR7 | |
| SCHEMBL4373680 | 0.84 | KDR (0.51) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |