Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
| ▸ | ITGAV | P06756 | 2/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17492385 | 0.79 | SMN1; SMN2 (0.51) | SLC1A3SLC1A2SLC1A1ALDH1A1L3MBTL1 | |
| SCHEMBL3908615 | 0.79 | PSEN1 (0.59) | SLC1A3SLC1A2SLC1A1ITGAVNR3C1 | |
| SCHEMBL3198196 | 0.77 | NR3C1 (0.46) | ITGAVNR3C1ALDH1A1ALOX5APFEN1 | |
| SCHEMBL1716735 | 0.77 | MMP2 (0.49) | SLC1A3SLC1A2SLC1A1ALDH1A1TSHR | |
| SCHEMBL1716737 | 0.77 | MMP2 (0.49) | SLC1A3SLC1A2SLC1A1ALDH1A1TSHR | |
| SCHEMBL28878517 | 0.74 | SLC1A3 (0.46) | SLC1A3SLC1A2SLC1A1ITGAVNR3C1 | |
| SCHEMBL1734801 | 0.74 | ITGAV (0.67) | SLC1A3SLC1A2SLC1A1ITGAVCTSL | |
| SCHEMBL1734803 | 0.74 | ITGAV (0.67) | SLC1A3SLC1A2SLC1A1ITGAVCTSL | |
| Gsi-136 SCHEMBL27544047 | 0.73 | PSEN1 (0.66) | KMT2AALDH1A1GAATSHRHTT | |
| Gsi-136 SCHEMBL1168789 | 0.73 | PSEN1 (0.66) | KMT2AALDH1A1GAATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549306-A4 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH CORP (US) | 2007-06-06 | — | — | EP | disclosed |
| EP-1549306-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2003103660-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2003-12-18 | — | — | WO | disclosed |