Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 5/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.32 |
| ▸ | GPR4 | P46093 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4390004 | 0.84 | FFAR4 (0.39) | KCNH2SLC6A4SLC6A2TACR1HTR2C | |
| SCHEMBL2785289 | 0.82 | FFAR4 (0.43) | SLC6A4SLC6A2TACR1HTR2CP2RX7 | |
| SCHEMBL5499318 | 0.82 | KCNH2 (0.33) | KCNH2SLC6A4SLC6A2CYP2D6TACR1 | |
| SCHEMBL5500092 | 0.79 | FFAR4 (0.43) | KCNH2SLC6A4SLC6A2TACR1P2RX7 | |
| SCHEMBL5502120 | 0.77 | SLC6A2 (0.38) | KCNH2SLC6A4SLC6A2CYP2D6TACR1 | |
| SCHEMBL5493818 | 0.76 | FFAR4 (0.41) | KCNH2SLC6A4SLC6A2TACR1HTR2C | |
| SCHEMBL5495876 | 0.75 | FFAR4 (0.38) | SLC6A4SLC6A2HTR2CREN | |
| SCHEMBL27618109 | 0.75 | TAAR1 (0.43) | SLC6A4SLC6A2CYP2D6HTR2CCYP3A4 | |
| SCHEMBL5499363 | 0.74 | TACR1 (0.43) | SLC6A4SLC6A2TACR1HTR2CP2RX7 | |
| Hydrochloric Acid SCHEMBL1475155 | 0.74 | TAAR1 (0.42) | SLC6A4SLC6A2CYP2D6HTR2CCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |