Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495293 | 0.87 | P2RX7 (0.38) | SLC6A2SLC6A4KCNH2CYP2D6SLC6A3 | |
| SCHEMBL5499016 | 0.83 | KCNH2 (0.38) | SLC6A2SLC6A4KCNH2CYP2D6SLC6A3 | |
| SCHEMBL2785289 | 0.81 | FFAR4 (0.43) | SLC6A2SLC6A4HTR2CFFAR4TACR1 | |
| SCHEMBL4390004 | 0.81 | FFAR4 (0.39) | SLC6A2SLC6A4KCNH2SLC6A3HTR2C | |
| SCHEMBL5493839 | 0.80 | P2RX7 (0.39) | SLC6A2SLC6A4KCNH2CYP2D6SLC6A3 | |
| SCHEMBL5493818 | 0.79 | FFAR4 (0.41) | SLC6A2SLC6A4KCNH2SLC6A3HTR2C | |
| SCHEMBL5499046 | 0.79 | CCR1 (0.38) | SLC6A2SLC6A4CYP2D6SLC6A3HTR2B | |
| SCHEMBL5499100 | 0.77 | KCNH2 (0.41) | SLC6A2SLC6A4KCNH2CYP2D6HTR2C | |
| SCHEMBL5494489 | 0.76 | SLC6A2 (0.40) | SLC6A2SLC6A4KCNH2CYP2D6SLC6A3 | |
| SCHEMBL5499363 | 0.74 | TACR1 (0.43) | SLC6A2SLC6A4SLC6A3HTR2CFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| EP-1768958-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF DOPAMINE AND SEROTONIN NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-04 | — | — | EP | disclosed |
| WO-2005121088-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF DOPAMINE AND SEROTONIN NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |