Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550534 | 1.00 | HSD11B1 (0.36) | HSD11B1CXCR3CYP2D6HSD17B10ALDH1A1 | |
| SCHEMBL2699742 | 1.00 | HSD11B1 (0.36) | HSD11B1CXCR3CYP2D6HSD17B10ALDH1A1 | |
| SCHEMBL549516 | 1.00 | HSD11B1 (0.36) | HSD11B1CXCR3CYP2D6HSD17B10ALDH1A1 | |
| SCHEMBL549517 | 1.00 | HSD11B1 (0.36) | HSD11B1CXCR3CYP2D6HSD17B10ALDH1A1 | |
| SCHEMBL549917 | 1.00 | HSD11B1 (0.36) | HSD11B1CXCR3CYP2D6HSD17B10ALDH1A1 | |
| SCHEMBL2699981 | 1.00 | HSD11B1 (0.36) | HSD11B1CXCR3CYP2D6HSD17B10ALDH1A1 | |
| SCHEMBL549983 | 1.00 | HSD11B1 (0.36) | HSD11B1CXCR3CYP2D6HSD17B10ALDH1A1 | |
| SCHEMBL2699738 | 1.00 | HSD11B1 (0.36) | HSD11B1CXCR3CYP2D6HSD17B10ALDH1A1 | |
| SCHEMBL5631229 | 0.89 | CXCR3 (0.38) | HSD11B1CXCR3OPRM1OPRL1HCRTR2 | |
| SCHEMBL4720344 | 0.89 | CXCR3 (0.38) | HSD11B1CXCR3OPRM1OPRL1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |