Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.34 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550441 | 1.00 | HSD11B1 (0.44) | HSD11B1POLBMEN1KMT2ANOTUM | |
| SCHEMBL2699812 | 1.00 | HSD11B1 (0.44) | HSD11B1POLBMEN1KMT2ANOTUM | |
| SCHEMBL2699815 | 1.00 | HSD11B1 (0.44) | HSD11B1POLBMEN1KMT2ANOTUM | |
| SCHEMBL549967 | 1.00 | HSD11B1 (0.44) | HSD11B1POLBMEN1KMT2ANOTUM | |
| SCHEMBL550442 | 1.00 | HSD11B1 (0.44) | HSD11B1POLBMEN1KMT2ANOTUM | |
| SCHEMBL17082128 | 0.92 | HSD11B1 (0.42) | HSD11B1NOTUMHTR1A | |
| SCHEMBL551282 | 0.92 | HSD11B1 (0.42) | HSD11B1NOTUMHTR1A | |
| SCHEMBL2699453 | 0.92 | HSD11B1 (0.42) | HSD11B1NOTUMHTR1A | |
| SCHEMBL549455 | 0.92 | HSD11B1 (0.42) | HSD11B1NOTUMHTR1A | |
| SCHEMBL4570194 | 0.92 | HSD11B1 (0.42) | HSD11B1NOTUMHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |