Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | ATR | Q13535 | 2/20 | 0.58 |
| ▸ | FLT3 | P36888 | 2/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.54 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.53 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11482696 | 0.88 | MEN1 (0.57) | MAPTMEN1TP53TSHRKMT2A | |
| SCHEMBL6037559 | 0.88 | RAB9A (0.61) | MAPTMEN1TP53TSHRKMT2A | |
| SCHEMBL6037554 | 0.88 | MEN1 (0.57) | MAPTMEN1TP53TSHRKMT2A | |
| SCHEMBL7570488 | 0.88 | MEN1 (0.57) | MAPTMEN1TP53TSHRKMT2A | |
| SCHEMBL2230478 | 0.81 | RAB9A (0.60) | MAPTMEN1TP53TSHRKMT2A | |
| SCHEMBL6811232 | 0.81 | FLT3 (0.58) | MAPTMEN1TP53TSHRKMT2A | |
| SCHEMBL25474761 | 0.80 | RAB9A (0.58) | MAPTMEN1TP53TSHRKMT2A | |
| SCHEMBL5655604 | 0.80 | RAB9A (0.62) | MAPTMEN1TP53TSHRKMT2A | |
| SCHEMBL30956107 | 0.80 | RAB9A (0.58) | MAPTMEN1TP53TSHRKMT2A | |
| SCHEMBL13306750 | 0.80 | RAB9A (0.58) | MAPTMEN1TP53TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072496-A | Preparation method of isoquinoline-1-formamide compound | 湖北工业大学 | 2021-07-06 | — | — | CN | disclosed |
| EP-1667979-A4 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2007-04-18 | — | — | EP | disclosed |
| EP-1667979-A2 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030130-A2 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | disclosed |
| US-4232160-A | Isoquinoline propionamides exhibiting analgesic properties | MILES LABORATORIES, INC. (US) | 1980-11-04 | — | — | US | disclosed |