Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30785203 | 0.89 | MDM4 (0.49) | MDM4TP53CASP3KMT2APIN1 | |
| SCHEMBL1738680 | 0.89 | MDM4 (0.49) | MDM4TP53CASP3KMT2APIN1 | |
| SCHEMBL28341996 | 0.89 | MDM4 (0.49) | MDM4TP53CASP3KMT2APIN1 | |
| SCHEMBL8037756 | 0.89 | MDM4 (0.49) | MDM4TP53CASP3KMT2APIN1 | |
| SCHEMBL7713562 | 0.88 | CASP3 (0.49) | MDM4TP53CASP3KMT2ATNF | |
| SCHEMBL22433817 | 0.88 | CASP3 (0.49) | MDM4TP53CASP3KMT2ATNF | |
| SCHEMBL1737738 | 0.88 | CASP3 (0.49) | MDM4TP53CASP3KMT2ATNF | |
| SCHEMBL29908049 | 0.88 | CASP3 (0.49) | MDM4TP53CASP3KMT2ATNF | |
| SCHEMBL15521327 | 0.88 | CASP3 (0.49) | MDM4TP53CASP3KMT2ATNF | |
| SCHEMBL7713563 | 0.88 | CASP3 (0.49) | MDM4TP53CASP3KMT2ATNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858538-A2 | MUCIN HYPERSECRETION INHIBITORS BASED ON THE STRUCTURE OF MANS AND METHODS OF USE | Biomarck Pharmaceuticals, Ltd. (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006078899-A2 | MUCIN HYPERSECRETION INHIBITORS BASED ON THE STRUCTURE OF MANS AND METHODS OF USE | BIOMARCK PHARMACEUTICALS, LTD. (US) | 2006-07-27 | — | — | WO | disclosed |