Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.35 |
| ▸ | MTOR | P42345 | 4/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.34 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549960 | 1.00 | HSD11B1 (0.35) | HSD11B1PIK3CAMTORAKT1HCRTR1 | |
| SCHEMBL2700933 | 1.00 | HSD11B1 (0.35) | HSD11B1PIK3CAMTORAKT1HCRTR1 | |
| SCHEMBL550025 | 1.00 | HSD11B1 (0.35) | HSD11B1PIK3CAMTORAKT1HCRTR1 | |
| SCHEMBL549959 | 1.00 | HSD11B1 (0.35) | HSD11B1PIK3CAMTORAKT1HCRTR1 | |
| SCHEMBL2700934 | 1.00 | HSD11B1 (0.35) | HSD11B1PIK3CAMTORAKT1HCRTR1 | |
| SCHEMBL550543 | 0.84 | HCRTR1 (0.36) | HSD11B1PIK3CAMTORHCRTR1HCRTR2 | |
| SCHEMBL550544 | 0.84 | HCRTR1 (0.36) | HSD11B1PIK3CAMTORHCRTR1HCRTR2 | |
| SCHEMBL551680 | 0.84 | HCRTR1 (0.36) | HSD11B1PIK3CAMTORHCRTR1HCRTR2 | |
| SCHEMBL551681 | 0.84 | HCRTR1 (0.36) | HSD11B1PIK3CAMTORHCRTR1HCRTR2 | |
| SCHEMBL2698071 | 0.84 | HCRTR1 (0.36) | HSD11B1PIK3CAMTORHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |