Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550543 | 1.00 | HCRTR1 (0.36) | HCRTR1HCRTR2HTR1ATSPOTSHR | |
| SCHEMBL2698071 | 1.00 | HCRTR1 (0.36) | HCRTR1HCRTR2HTR1ATSPOTSHR | |
| SCHEMBL550544 | 1.00 | HCRTR1 (0.36) | HCRTR1HCRTR2HTR1ATSPOTSHR | |
| SCHEMBL2698066 | 1.00 | HCRTR1 (0.36) | HCRTR1HCRTR2HTR1ATSPOTSHR | |
| SCHEMBL551681 | 1.00 | HCRTR1 (0.36) | HCRTR1HCRTR2HTR1ATSPOTSHR | |
| SCHEMBL4570110 | 0.94 | ALDH1A1 (0.43) | HCRTR1HCRTR2TSHRALDH1A1HPGD | |
| SCHEMBL549959 | 0.84 | HSD11B1 (0.35) | HCRTR1HCRTR2HTR1ATSPOHSD11B1 | |
| SCHEMBL550026 | 0.84 | HSD11B1 (0.35) | HCRTR1HCRTR2HTR1ATSPOHSD11B1 | |
| SCHEMBL549960 | 0.84 | HSD11B1 (0.35) | HCRTR1HCRTR2HTR1ATSPOHSD11B1 | |
| SCHEMBL2700934 | 0.84 | HSD11B1 (0.35) | HCRTR1HCRTR2HTR1ATSPOHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |