SCHEMBL5500495

SCHEMBL5500495

CCCCc1cc(N=C=O)ccc1C

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.53
TRPA1 O75762 1/20 0.53
MAPK1 P28482 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
TSHR P16473 1/20 0.38
GABRA1 P14867 1/20 0.36
GABRB2 P47870 1/20 0.36
TYR P14679 2/20 0.34
MAPT P10636 2/20 0.34
HTT P42858 1/20 0.34
SKP2 Q13309 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP1A2 P05177 1/20 0.33
TAAR1 Q96RJ0 1/20 0.33
CTRC Q99895 1/20 0.32
MAOA P21397 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.31
EGFR P00533 1/20 0.31
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24999152 0.84 CYP3A4 (0.61) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL10584311 0.84 CYP3A4 (0.50) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL28797337 0.84 CYP3A4 (0.49) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL27337743 0.83 CYP3A4 (0.49) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL10967904 0.83 CYP3A4 (0.41) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL10966469 0.83 CYP3A4 (0.41) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL3975605 0.81 CYP3A4 (0.61) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL9129475 0.81 CYP3A4 (0.53) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL9029718 0.79 GABRP (0.46) CYP3A4TRPA1MAPK1TDP1GABRA1
SCHEMBL10963525 0.79 CYP3A4 (0.41) CYP3A4TRPA1MAPK1TDP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1861357-A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME Amorepacific Corporation (KR) 2007-12-05 EP disclosed
WO-2006101318-A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AMOREPACIFIC CORPORATION (KR) 2006-09-28 WO disclosed