Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 15/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.73 |
| ▸ | DRD2 | P14416 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120452 | 0.91 | PTGDR2 (1.00) | PTGDR2 | |
| SCHEMBL5107201 | 0.81 | PTGDR2 (1.00) | PTGDR2MEN1KMT2A | |
| SCHEMBL11887749 | 0.80 | PTGDR2 (0.75) | PTGDR2MEN1KMT2A | |
| SCHEMBL5107724 | 0.80 | PTGDR2 (1.00) | PTGDR2 | |
| SCHEMBL5118599 | 0.79 | PTGDR2 (0.76) | PTGDR2MEN1KMT2A | |
| SCHEMBL5112266 | 0.78 | PTGDR2 (1.00) | PTGDR2 | |
| SCHEMBL9683188 | 0.78 | L3MBTL1 (0.74) | PTGDR2TBXA2RDRD2MEN1KMT2A | |
| SCHEMBL5114577 | 0.78 | PTGDR2 (0.64) | PTGDR2TBXA2RDRD2HDAC3HDAC4 | |
| SCHEMBL5116168 | 0.77 | HPGD (1.00) | PTGDR2KMT2A | |
| SCHEMBL15685953 | 0.77 | PTGDR2 (0.73) | PTGDR2HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |